Details:

Alternative Title:
Prev Chronic Dis
Publisher's site:
http://dx.doi.org/10.5888/pcd14.170196
Personal Author:
Polinski, Kristen J. ; Liu, Jihong ; Boghossian, Nansi S. ; McLain, Alexander C.
Polinski, Kristen J. ; Liu, Jihong ; Boghossian, Nansi S. ; McLain, Alexander C. Less -
Description:
Introduction

Obesity is common among women of childbearing age; intrauterine exposure to maternal obesity or gestational weight gain may influence the development of asthma in early childhood. We examined the relationships of maternal obesity and gestational weight gain with asthma in offspring.

Methods

We used data from the Early Childhood Longitudinal Study–Birth Cohort, which has a nationally representative sample of children followed from birth in 2001 through age 4 (n = 6,450). Asthma was based on parental report of a medical professional’s diagnosis. We used generalized estimating equation binomial models to compute adjusted odds ratios (ORs) of childhood asthma with maternal obesity and 4 measures of gestational weight gain.

Results

Compared with children of normal-weight mothers, children of obese mothers had increased risk of asthma (adjusted OR, 1.63; 95% confidence interval [CI], 1.26–2.12) by age 4, and children born to overweight mothers had similar risk (adjusted OR, 1.25; 95% CI, 0.99–1.59). Extreme-low weight gain (<5 kg) and extreme-high weight gain (≥25 kg) were associated with increased risk of asthma; however, the following measures were not significant predictors of asthma: meeting gestational weight gain recommendations of the Institute of Medicine, total gestational weight gain, and weekly rate of weight gain in the second and third trimesters.

Conclusion

Extreme-low or extreme-high gestational weight gain and maternal obesity are risk factors for early childhood asthma, further evidence of the long-term impact of intrauterine exposure on children and the need to target preconception care to improve child health indicators.


Subject:
[+]
Adult
Asthma
Child
Child, Preschool
Female
Humans
Longitudinal Studies
Male
Mothers
Obesity
Odds Ratio
Pregnancy
Pregnancy Complications
Risk Factors
Weight Gain

Source:
Prev Chronic Dis. 14.
Pubmed ID:
29120703
Pubmed Central ID:
PMC5695645
Document Type:
Journal Article
Collection(s):
Preventing Chronic Disease
Main Document Checksum:
[+]
urn:sha256:eb84bdc116c90f297764518be1399df8578c0627d05186ce2d36030f081278cc
File Type:

Supporting Files

• PCD-14-E109.nxml

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