Details:

Alternative Title:
Environ Res
Publisher's site:
http://dx.doi.org/10.1016/j.envres.2016.03.015
Personal Author:
Feroe, Aliya G. ; Attanasio, Roberta ; Scinicariello, Franco
Feroe, Aliya G. ; Attanasio, Roberta ; Scinicariello, Franco Less -
Description:
Acrolein is a dietary and environmental pollutant that has been associated in vitro to dysregulate glucose transport. We investigated the association of urinary acrolein metabolites N-acetyl-S-(3-hydroxypropyl)-l-cysteine (3-HPMA) and N-acetyl-S-(carboxyethyl)-l-cysteine (CEMA) and their molar sum (∑acrolein) with diabetes using data from investigated 2027 adults who participated in the 2005-2006 National Health and Nutrition Examination Survey (NHANES). After excluding participants taking insulin or other diabetes medication we, further, investigated the association of the compounds with insulin resistance (n=850), as a categorical outcome expressed by the homeostatic model assessment (HOMA-IR>2.6). As secondary analyses, we investigated the association of the compounds with HOMA-IR, HOMA-β, fasting insulin and fasting plasma glucose. The analyses were performed using urinary creatinine as independent variable in the models, and, as sensitivity analyses, the compounds were used as creatinine corrected variables. Diabetes as well as insulin resistance (defined as HOMA-IR>2.6) were positively associated with the 3-HPMA, CEMA and ∑Acrolein with evidence of a dose-response relationship (p<0.05). The highest 3rd and 4th quartiles of CEMA compared to the lowest quartile were significantly associated with higher HOMA-IR, HOMA-β and fasting insulin with a dose-response relationship. The highest 3rd quartile of 3-HPMA and ∑Acrolein were positively and significantly associated with HOMA-IR, HOMA-β and fasting insulin. These results suggest a need of further studies to fully understand the implications of acrolein with type 2 diabetes and insulin.
Subject:
[+]
Acetylcysteine
Acrolein
Adult
Article
Diabetes Mellitus, Type 2
Dose-Response Relationship, Drug
Female
HOMA
Humans
Insulin Resistance
Male
N-acetyl-S-(3-hydroxypropyl)-L-cysteine
N-acetyl-S-(carboxyethyl)-L-cysteine
NHANES
Nutrition Surveys

Source:
Environ Res. 148:1-6.
Pubmed ID:
26991531
Pubmed Central ID:
PMC5700808
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:21c25f403655e6d1541473e57844100d476e01026bdfe753526fb94425fcd9d6
File Type:

Supporting Files

• 	NIHMS918320-supplement-Supplementa_Tables.docx	docx
  	nihms918320.nxml	xml

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