Serum Total Testosterone Concentrations in the US Household Population from the NHANES 2011–2012 Study Population

Details

• Alternative Title:
  Clin Chem
• Personal Author:
  Vesper, Hubert W. ; Wang, Yuesong ; Vidal, Meghan ; Botelho, Julianne Cook ; Caudill, Samuel P.
• Description:
  BACKGROUND
  
  Limited information is available about testosterone concentrations representative of the general US population, especially children, women, and non-Hispanic Asians.
  
  METHODS
  
  We obtained nationally representative data for total testosterone (totalT), measured with standardized LC-MS/MS, for the US population age 6 years and older from the 2011–2012 National Health and Nutrition Examination Survey (NHANES). We analyzed 6746 serum samples and calculated the geometric means, distribution percentiles, and covariate-adjusted geometric means by age, sex, and race/ethnicity.
  
  RESULTS
  
  The 10th–90th percentiles of totalT values in adults (≥20 years) was 150–698 ng/dL (5.20–24.2 nmol/L) in men, 7.1–49.8 ng/dL (0.25–1.73 nmol/L) in women, and 1.0–9.5 ng/dL (0.04–0.33 nmol/L) in children (6–10 years old). Differences among race/ethnic groups existed in children and men: covariate-adjusted totalT values in non-Hispanic Asians were highest among children (58% compared to non-Hispanic black children) and lowest among men (12% compared to Mexican-American men). Covariate-adjusted totalT values in men were higher at age 55–60 years compared to ages 35 and 80 years, a pattern different from that observed in previous NHANES cycles.
  
  CONCLUSIONS
  
  TotalT patterns were different among age groups in men compared with previous NHANES cycles. Covariate-adjusted totalT values peaked at age 55–60 years in men, which appeared to be consistent with the increased use of exogenous testosterone. Differences among race/ethnic groups existed and appeared more pronounced in children than adults.
  
  
• Subjects:
  Adolescent Adult Aged Aged, 80 And Over Asian People Black People Child Chromatography, Liquid Female Humans Male Mexican Americans Middle Aged Nutrition Surveys Tandem Mass Spectrometry Testosterone White People

  More +
• Source:
  Clin Chem. 61(12):1495-1504
• Pubmed ID:
  26510959
• Pubmed Central ID:
  PMC5698798
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Place as Subject:
  United States
• Volume:
  61
• Issue:
  12
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:ea3d71c45e8d0e193664a56a1d0fce71c4257cc3b7956d11233f4c6ff52f0ae2
• Download URL:
  https://stacks.cdc.gov/view/cdc/49949/cdc_49949_DS1.pdf
• File Type:
  [PDF - 749.78 KB ]