Details:

Alternative Title:
Virology
Publisher's site:
http://dx.doi.org/10.1016/j.virol.2014.12.024
Personal Author:
Yang, Hua ; Carney, Paul J. ; Chang, Jessie C. ; Guo, Zhu ; Villanueva, Julie M. ; ... More +
Yang, Hua ; Carney, Paul J. ; Chang, Jessie C. ; Guo, Zhu ; Villanueva, Julie M. ; Stevens, James Less -
Description:
A(H3N2) influenza viruses have circulated in humans since 1968, and antigenic drift of the hemagglutinin (HA) protein continues to be a driving force that allows the virus to escape the human immune response. Since the major antigenic sites of the HA overlap into the receptor binding site (RBS) of the molecule, the virus constantly struggles to effectively adapt to host immune responses, without compromising its functionality. Here, we have structurally assessed the evolution of the A(H3N2) virus HA RBS, using an established recombinant expression system. Glycan binding specificities of nineteen A(H3N2) influenza virus HAs, each a component of the seasonal influenza vaccine between 1968 and 2012, were analyzed. Results suggest that while its receptor-binding site has evolved from one that can bind a broad range of human receptor analogs to one with a more restricted binding profile for longer glycans, the virus continues to circulate and transmit efficiently among humans.
Subject:
[+]
Article
Evolution, Molecular
Glycan Microarray
H3N2
Hemagglutinin
Hemagglutinin Glycoproteins, Influenza Virus
Humans
Influenza, Human
Influenza A Virus, H3N2 Subtype
Influenza Virus
Mutant Proteins
Protein Binding
Receptors, Virus
Receptor Specificity

Source:
Virology. 477:18-31.
Pubmed ID:
25617824
Pubmed Central ID:
PMC5696785
Document Type:
Journal Article
Funding:
P41GM103393/GM/NIGMS NIH HHS/United States ; CC999999/Intramural CDC HHS/United States ; GM62116/GM/NIGMS NIH HHS/United States ; U54 GM062116/GM/NIGMS NIH HHS/United States ; P41 GM103393/GM/NIGMS NIH HHS/United States
P41GM103393/GM/NIGMS NIH HHS/United States ; CC999999/Intramural CDC HHS/United States ; GM62116/GM/NIGMS NIH HHS/United States ; U54 GM062116/GM/NIGMS NIH HHS/United States ; P41 GM103393/GM/NIGMS NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:8d71656ac81e79bd525e6fc7eae5494a3d322559e86f6171e3b1bc6a5094d479
File Type:

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