Prenatal Alcohol Exposure in Relation to Autism Spectrum Disorder: Findings from the Study to Explore Early Development (SEED)

Singer, Alison B.; Aylsworth, Arthur S.; Cordero, Christina; Croen, Lisa A.; DiGuiseppi, Carolyn; Fallin, M. Daniele; Herring, Amy H.; Hooper, Stephen R.; Pretzel, Rebecca E.; Schieve, Laura A.; Windham, Gayle C.; Daniels, Julie L.

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Prenatal Alcohol Exposure in Relation to Autism Spectrum Disorder: Findings from the Study to Explore Early Development (SEED)

Published Date:

Sep 07 2017

Source:

Paediatr Perinat Epidemiol. 31(6):573-582.

Language:

English

[PDF-191.17 KB]

Details:

Personal Authors:

Singer, Alison B. ; Aylsworth, Arthur S. ; Cordero, Christina ; Croen, Lisa A. ; DiGuiseppi, Carolyn ; ... More ▼

Keywords:

[+]

Pubmed ID:

28881390

Pubmed Central ID:

PMC5690833

Description:

Background

Prenatal alcohol exposure can affect neurodevelopment, but few studies have examined associations with autism spectrum disorder (ASD).

Methods

We assessed the association between maternal alcohol use and ASD in the Study to Explore Early Development, a multi-site case-control study of children born September 2003 – August 2006 in the U.S. Regression analyses included 684 children with research clinician-confirmed ASD, 869 children with non-ASD developmental delays or disorders (DDs) and 962 controls ascertained from the general population (POP). Maternal alcohol exposure during each month from three months prior to conception until delivery was assessed by self-report.

Results

Mothers of POP children were more likely to report any prenatal alcohol use than mothers of children with ASD or DD. In trimester one, 21.2% of mothers of POP children reported alcohol use compared to 18.1% and 18.2% of mothers of children with ASD or DD, respectively (adjusted OR for ASD versus POP 0.8, 95% confidence interval 0.6, 1.1). During preconception and the first month of pregnancy, 1–2 drinks on average per week was inversely associated with ASD risk.

Conclusions

These results do not support an adverse association between low-level alcohol exposure and ASD, though these findings were based retrospective self-reported alcohol use. Unmeasured confounding or exposure misclassification may explain inverse associations with 1–2 drinks per week. Pregnant or potentially pregnant women should continue to follow recommendations to avoid alcohol use because of other known effects on infant health and neurodevelopment.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

U10 DD000180/DD/NCBDD CDC HHS/United States
T32 ES007018/ES/NIEHS NIH HHS/United States
U10 DD000181/DD/NCBDD CDC HHS/United States
U10 DD000184/DD/NCBDD CDC HHS/United States
U01 DD001210/DD/NCBDD CDC HHS/United States
U01 DD000498/DD/NCBDD CDC HHS/United States
U01 DD001205/DD/NCBDD CDC HHS/United States
U01 DD000750/DD/NCBDD CDC HHS/United States
U10 DD000182/DD/NCBDD CDC HHS/United States
U10 DD000183/DD/NCBDD CDC HHS/United States

Main Document Checksum:

[+]

Supporting Files:

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