Details:

Alternative Title:
Paediatr Perinat Epidemiol
Personal Author:
Singer, Alison B.; Aylsworth, Arthur S.; Cordero, Christina; Croen, Lisa A.; DiGuiseppi, Carolyn; ... More +
Singer, Alison B.; Aylsworth, Arthur S.; Cordero, Christina; Croen, Lisa A.; DiGuiseppi, Carolyn; Fallin, M. Daniele; Herring, Amy H.; Hooper, Stephen R.; Pretzel, Rebecca E.; Schieve, Laura A.; Windham, Gayle C.; Daniels, Julie L.; Less -
Description:
Background Prenatal alcohol exposure can affect neurodevelopment, but few studies have examined associations with autism spectrum disorder (ASD). Methods We assessed the association between maternal alcohol use and ASD in the Study to Explore Early Development, a multi-site case-control study of children born September 2003 – August 2006 in the U.S. Regression analyses included 684 children with research clinician-confirmed ASD, 869 children with non-ASD developmental delays or disorders (DDs) and 962 controls ascertained from the general population (POP). Maternal alcohol exposure during each month from three months prior to conception until delivery was assessed by self-report. Results Mothers of POP children were more likely to report any prenatal alcohol use than mothers of children with ASD or DD. In trimester one, 21.2% of mothers of POP children reported alcohol use compared to 18.1% and 18.2% of mothers of children with ASD or DD, respectively (adjusted OR for ASD versus POP 0.8, 95% confidence interval 0.6, 1.1). During preconception and the first month of pregnancy, 1–2 drinks on average per week was inversely associated with ASD risk. Conclusions These results do not support an adverse association between low-level alcohol exposure and ASD, though these findings were based retrospective self-reported alcohol use. Unmeasured confounding or exposure misclassification may explain inverse associations with 1–2 drinks per week. Pregnant or potentially pregnant women should continue to follow recommendations to avoid alcohol use because of other known effects on infant health and neurodevelopment.
Subject:
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Adult
Alcohol Drinking
Autism Spectrum Disorder
Central Nervous System Depressants
Child
Child Development
Ethanol
Female
Humans
Pregnancy
Pregnant Women
Prenatal Exposure Delayed Effects
Risk Assessment
Risk Factors

Source:
Paediatr Perinat Epidemiol. 31(6):573-582.;
Pubmed ID:
28881390
Pubmed Central ID:
PMC5690833
Document Type:
Journal Article;
Funding:
U10 DD000180/DD/NCBDD CDC HHS/United States; T32 ES007018/ES/NIEHS NIH HHS/United States; U10 DD000181/DD/NCBDD CDC HHS/United States; U10 DD000184/DD/NCBDD CDC HHS/United States; U01 DD001210/DD/NCBDD CDC HHS/United States; ... More +
U10 DD000180/DD/NCBDD CDC HHS/United States; T32 ES007018/ES/NIEHS NIH HHS/United States; U10 DD000181/DD/NCBDD CDC HHS/United States; U10 DD000184/DD/NCBDD CDC HHS/United States; U01 DD001210/DD/NCBDD CDC HHS/United States; U01 DD000498/DD/NCBDD CDC HHS/United States; U01 DD001205/DD/NCBDD CDC HHS/United States; U01 DD000750/DD/NCBDD CDC HHS/United States; U10 DD000182/DD/NCBDD CDC HHS/United States; U10 DD000183/DD/NCBDD CDC HHS/United States; Less -
Place as Subject:
United States;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:2f8edfbe47f96383561c9466f3ec7c104107d75912a373db805b31ce1cef5b8d
File Type:

Supporting Files

• 	NIHMS898195-supplement-Supp_info.docx	docx
  	nihms898195.nxml	xml
  	nihms898195f1.gif	gif
  	nihms898195f1.jpg	jpeg
  	nihms898195f2.gif	gif
  	nihms898195f2.jpg	jpeg

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