Details:

Alternative Title:
Hepatology
Publisher's site:
http://dx.doi.org/10.1002/hep.27422
Personal Author:
Boscarino, Joseph A. ; Lu, Mei ; Moorman, Anne C. ; Gordon, Stuart C. ; Rupp, Loralee B. ; ... More +
Boscarino, Joseph A. ; Lu, Mei ; Moorman, Anne C. ; Gordon, Stuart C. ; Rupp, Loralee B. ; Spradling, Philip R. ; Teshale, Eyasu H. ; Schmidt, Mark A. ; Vijayadeva, Vinutha ; Holmberg, Scott D. Less -
Description:
Aims

Our objective was to assess the extent and risk factors for depression and poor physical health among patients with chronic hepatitis C virus (HCV) infection.

Methods

We surveyed HCV-infected patients seen at four large healthcare systems participating in the Chronic Hepatitis Cohort Study (CHeCS). Survey data included demographics, depression and physical health measures, substance use history, current social support, recent stressor exposures, and, from the electronic medical record, treatment history, and Charlson Comorbidity Index scores.

Results

There were 4,781 respondents, who were a mean of 57 years old, 71% White, and 57% male. Altogether, 51.4% reported past injection drug use, 33.9% were current smokers, and 17.7% had abused alcohol in the previous year. Additionally, 47.4% had been previously treated for HCV and 14.8% had a 12-week sustained viral response (SVR) following HCV therapy. Overall, 29.7% of patients met criteria for current depression and 24.6% were in poor physical health. In multivariate analyses, significant predictors of depression and poor health included: male gender (vs. female, OR, 0.70 and 0.81), Black race (vs. white, ORs, 0.60 and 0.61), having education less than high school (vs. college, ORs, 1.81 and 1.54), being employed (vs. not, ORs, 0.36 and 0.25), having high life stressors (vs. low, ORs, 2.44 and 1.64), having low social support (vs. high, ORs=2.78 and 1.40), and having high Charlson scores (vs. none, ORs=1.58 and 2.12). Achieving a 12- week SVR was found to be protective for depression.

Conclusions

This large survey of US HCV patients indicates the extent of adverse health behaviors and mental and physical comorbidities among these patients.


Subject:
[+]
Adult
Aged
Article
Cohort Studies
Depression
Female
Health Status
Hepatitis C
Hepatitis C, Chronic
Humans
Male
Mental Health
Middle Aged
Quality Of Life
Risk Factors
Social Support

Source:
Hepatology. 61(3):802-811.
Pubmed ID:
25203533
Pubmed Central ID:
PMC5675518
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States ; U18 PS005154/PS/NCHHSTP CDC HHS/United States
CC999999/Intramural CDC HHS/United States ; U18 PS005154/PS/NCHHSTP CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:21008613a640c63d8aad03e1621baacf060faafdf36e8515fc27f14332072ea6
File Type:

Supporting Files

• nihms916070.nxml

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