Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Goto, Michihiko ; McDanel, Jennifer S. ; Jones, Makoto M. ; Livorsi, Daniel J. ; Ohl, Michael E. ; ... More +
Goto, Michihiko ; McDanel, Jennifer S. ; Jones, Makoto M. ; Livorsi, Daniel J. ; Ohl, Michael E. ; Beck, Brice F. ; Richardson, Kelly K. ; Alexander, Bruce ; Perencevich, Eli N. Less -
Description:
Bacteremia caused by gram-negative bacteria is associated with serious illness and death, and emergence of antimicrobial drug resistance in these bacteria is a major concern. Using national microbiology and patient data for 2003-2013 from the US Veterans Health Administration, we characterized nonsusceptibility trends of community-acquired, community-onset; healthcare-associated, community-onset; and hospital-onset bacteremia for selected gram-negative bacteria (Escherichia coli, Klebsiella spp., Pseudomonas aeruginosa, and Acinetobacter spp.). For 47,746 episodes of bacteremia, the incidence rate was 6.37 episodes/10,000 person-years for community-onset bacteremia and 4.53 episodes/10,000 patient-days for hospital-onset bacteremia. For Klebsiella spp., P. aeruginosa, and Acinetobacter spp., we observed a decreasing proportion of nonsusceptibility across nearly all antimicrobial drug classes for patients with healthcare exposure; trends for community-acquired, community-onset isolates were stable or increasing. The role of infection control and antimicrobial stewardship efforts in inpatient settings in the decrease in drug resistance rates for hospital-onset isolates needs to be determined.
Subject:
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Acinetobacter Aged Anti-Bacterial Agents Bacteremia Cohort Studies Drug Resistance, Bacterial Escherichia Coli Female Gram-Negative Bacteria Humans Klebsiella Male Pseudomonas Aeruginosa Research Retrospective Studies Veterans
Source:
Emerg Infect Dis. 23(11):1815-1825.
Pubmed ID:
29047423
Pubmed Central ID:
PMC5652419
Document Type:
Journal Article
Name as Subject:
United States. Department of Veterans Affairs.
Place as Subject:
United States
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:b0aae50ec4c35e10c8d9f9dde04d4c3a80b5c455fbacd40f60cfbba6fdf81c68
Download URL:
https://stacks.cdc.gov/view/cdc/49564/cdc_49564_DS1.pdf
File Type:

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