Antimicrobial Nonsusceptibility of Gram-Negative Bloodstream Isolates, Veterans Health Administration System, United States, 2003–20131

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Goto, Michihiko ; McDanel, Jennifer S. ; Jones, Makoto M. ; Livorsi, Daniel J. ; Ohl, Michael E. ; Beck, Brice F. ; Richardson, Kelly K. ; Alexander, Bruce ; Perencevich, Eli N.
• Description:
  Bacteremia caused by gram-negative bacteria is associated with serious illness and death, and emergence of antimicrobial drug resistance in these bacteria is a major concern. Using national microbiology and patient data for 2003-2013 from the US Veterans Health Administration, we characterized nonsusceptibility trends of community-acquired, community-onset; healthcare-associated, community-onset; and hospital-onset bacteremia for selected gram-negative bacteria (Escherichia coli, Klebsiella spp., Pseudomonas aeruginosa, and Acinetobacter spp.). For 47,746 episodes of bacteremia, the incidence rate was 6.37 episodes/10,000 person-years for community-onset bacteremia and 4.53 episodes/10,000 patient-days for hospital-onset bacteremia. For Klebsiella spp., P. aeruginosa, and Acinetobacter spp., we observed a decreasing proportion of nonsusceptibility across nearly all antimicrobial drug classes for patients with healthcare exposure; trends for community-acquired, community-onset isolates were stable or increasing. The role of infection control and antimicrobial stewardship efforts in inpatient settings in the decrease in drug resistance rates for hospital-onset isolates needs to be determined.
• Subjects:
  Acinetobacter Aged Anti-Bacterial Agents Bacteremia Cohort Studies Drug Resistance, Bacterial Escherichia Coli Female Gram-Negative Bacteria Humans Klebsiella Male Pseudomonas Aeruginosa Research Retrospective Studies Veterans

  More +
• Source:
  Emerg Infect Dis. 23(11):1815-1825.
• Pubmed ID:
  29047423
• Pubmed Central ID:
  PMC5652419
• Document Type:
  Journal Article
• Name as Subject:
  United States. Department of Veterans Affairs. ; United States. Department of Veterans Affairs.
• Place as Subject:
  United States
• Location:
  North America
• Volume:
  23
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:b0aae50ec4c35e10c8d9f9dde04d4c3a80b5c455fbacd40f60cfbba6fdf81c68
• Download URL:
  https://stacks.cdc.gov/view/cdc/49564/cdc_49564_DS1.pdf
• File Type:
  [PDF - 2.63 MB ]