Distribution and Diversity of Bartonella washoensis Strains in Ground Squirrels from California and Their Potential Link to Human Cases

Osikowicz, Lynn M.; Billeter, Sarah A.; Rizzo, Maria Fernanda; Rood, Michael P.; Freeman, Ashley N.; Burns, Joseph E.; Hu, Renjie; Juieng, Phalasy; Loparev, Vladimir; Kosoy, Michael

doi:10.1089/vbz.2016.2009

i

Distribution and Diversity of Bartonella washoensis Strains in Ground Squirrels from California and Their Potential Link to Human Cases

Supporting Files

11 2016
By Osikowicz, Lynn M. ; Billeter, Sarah A. ; Rizzo, Maria Fernanda ; ...

File Language:

English

Details

Alternative Title:

Vector Borne Zoonotic Dis
Personal Author:

Osikowicz, Lynn M. ; Billeter, Sarah A. ; Rizzo, Maria Fernanda ; Rood, Michael P. ; Freeman, Ashley N. ; Burns, Joseph E. ; Hu, Renjie ; Juieng, Phalasy ; Loparev, Vladimir ; Kosoy, Michael
Description:

We investigated the prevalence of Bartonella washoensis in California ground squirrels (Otospermophilus beecheyi) and their fleas from parks and campgrounds located in seven counties of California. Ninety-seven of 140 (69.3%) ground squirrels were culture positive and the infection prevalence by location ranged from 25% to 100%. In fleas, 60 of 194 (30.9%) Oropsylla montana were found to harbor Bartonella spp. when screened using citrate synthase (gltA) specific primers, whereas Bartonella DNA was not found in two other flea species, Hoplopsyllus anomalus (n = 86) and Echidnophaga gallinacea (n = 6). The prevalence of B. washoensis in O. montana by location ranged from 0% to 58.8%. A majority of the gltA sequences (92.0%) recovered from ground squirrels and fleas were closely related (similarity 99.4-100%) to one of two previously described strains isolated from human patients, B. washoensis NVH1 (myocarditis case in Nevada) and B. washoensis 08S-0475 (meningitis case in California). The results from this study support the supposition that O. beecheyi and the flea, O. montana, serve as a vertebrate reservoir and a vector, respectively, of zoonotic B. washoensis in California.
Subjects:

Animals Article Bartonella Bartonella Infections Bartonella Washoensis California Endocarditis, Bacterial Genetic Variation Ground Squirrel Humans Insect Vectors Meningitis, Bacterial Nevada Oropsylla Montana Otospermophilus Beecheyi Prevalence Sciuridae Siphonaptera Zoonoses
Source:

Vector Borne Zoonotic Dis. 16(11):683-690
Pubmed ID:

27705539
Pubmed Central ID:

PMC5663187
Document Type:

Journal Article
Funding:

CC999999/Intramural CDC HHSUnited States/
Volume:

16
Issue:

11
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:82323684d79abfce01445c5e0727723c86e17189be200964ece38799b16ba1f0
Download URL:

https://stacks.cdc.gov/view/cdc/49442/cdc_49442_DS1.pdf
File Type:

[PDF - 2.75 MB ]

File Language:

English

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