Details:

Alternative Title:
Antiviral Res
Personal Author:
Hotard, Anne L. ; He, Biao ; Nichol, Stuart T. ; Spiropoulou, Christina F. ; Lo, Michael K.
Hotard, Anne L. ; He, Biao ; Nichol, Stuart T. ; Spiropoulou, Christina F. ; Lo, Michael K. Less -
Description:
The henipaviruses Nipah virus and Hendra virus are highly pathogenic zoonotic paramyxoviruses which have caused fatal outbreaks of encephalitis and respiratory disease in humans. Despite the availability of a licensed equine Hendra virus vaccine and a neutralizing monoclonal antibody shown to be efficacious against henipavirus infections in non-human primates, there remains no approved therapeutics or vaccines for human use. To explore the possibility of developing small-molecule nucleoside inhibitors against henipaviruses, we evaluated the antiviral activity of 4'-azidocytidine (R1479), a drug previously identified to inhibit flaviviruses, against henipaviruses along with other representative members of the family Paramyxoviridae. We observed similar levels of R1479 antiviral activity across the family, regardless of virus genus. Our brief study expands the documented range of viruses susceptible to R1479, and provides the basis for future investigation and development of 4'-modified nucleoside analogs as potential broad-spectrum antiviral therapeutics across both positive and negative-sense RNA virus families.
Subjects:
[+]
Antiviral 4′-Azidocytidine Article Henipavirus Nipah Virus Nucleoside Analog
Source:
Antiviral Res. 144:147-152.
Pubmed ID:
28629988
Pubmed Central ID:
PMC5648002
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:658957d54155efd51183284bc3a8f45b992bfa102414ed28686dcfbc73e21b56
Download URL:
https://stacks.cdc.gov/view/cdc/49242/cdc_49242_DS1.pdf
File Type:

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