Details:

Alternative Title:
Sci Rep
Personal Author:
Muller, David A. ; Fernando, Germain J. P. ; Owens, Nick S. ; Agyei-Yeboah, Christiana ; Wei, Jonathan C. J. ; ... More +
Muller, David A. ; Fernando, Germain J. P. ; Owens, Nick S. ; Agyei-Yeboah, Christiana ; Wei, Jonathan C. J. ; Depelsenaire, Alexandra C. I. ; Forster, Angus ; Fahey, Paul ; Weldon, William C. ; Oberste, M. Steven ; Young, Paul R. ; Kendall, Mark A. F. Less -
Description:
To secure a polio-free world, the live attenuated oral poliovirus vaccine (OPV) will eventually need to be replaced with inactivated poliovirus vaccines (IPV). However, current IPV delivery is less suitable for campaign use than OPV, and more expensive. We are progressing a microarray patch delivery platform, the Nanopatch, as an easy-to-use device to administer vaccines, including IPV. The Nanopatch contains an ultra-high density array (10,000/cm|) of short (~230 μm) microprojections that delivers dry coated vaccine into the skin. Here, we compare the relative immunogenicity of Nanopatch immunisation versus intramuscular injection in rats, using monovalent and trivalent formulations of IPV. Nanopatch delivery elicits faster antibody response kinetics, with high titres of neutralising antibody after just one (IPV2) or two (IPV1 and IPV3) immunisations, while IM injection requires two (IPV2) or three (IPV1 and IPV3) immunisations to induce similar responses. Seroconversion to each poliovirus type was seen in 100% of rats that received ~1/40th of a human dose of IPV delivered by Nanopatch, but not in rats given ~1/8th or ~1/40th dose by IM injection. Ease of administration coupled with dose reduction observed in this study suggests the Nanopatch could facilitate inexpensive IPV vaccination in campaign settings.
Subjects:
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Cattle Factor XI Factor XII Kaolin Thromboplastin
Source:
Sci Rep. 7.
Pubmed Central ID:
PMC5626768
Document Type:
Journal Article
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:dc42b2d75ec25cb909d03ae8d79bd65b41f6f44b5144fe7ad8d879097ba9822a
Download URL:
https://stacks.cdc.gov/view/cdc/49199/cdc_49199_DS1.pdf
File Type:

Supporting Files

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