Persistent organic pollutants in infants and toddlers: Relationship between concentrations in matched plasma and faecal samples

Details

• Alternative Title:
  Environ Int
• Personal Author:
  Chen, Yiqin ; Sjodin, Andreas ; McLachlan, Michael S. ; English, Karin ; Aylward, Lesa L. ; Toms, Leisa-Maree L. ; Varghese, Julie ; Sly, Peter D. ; Mueller, Jochen F.
• Description:
  Early-childhood biomonitoring of persistent organic pollutants (POPs) is challenging due to the logistic and ethical limitations associated with blood sampling. We investigated using faeces as a non-invasive matrix to estimate internal exposure to POPs. The concentrations of selected POPs were measured in matched plasma and faecal samples collected from 20 infants/toddlers (aged 13±4.8months), including a repeat sample time point for 13 infants (~5months apart). We observed higher rates of POP quantification in faeces (2g dry weight) than in plasma (0.5mL). Among the five chemicals that had quantification frequencies over 50% in both matrices, except for HCB, log concentration in faeces (C|) and blood (C|) were correlated (r>0.74, P<0.05) for p.p'-dichlorodiphenyldichloroethylene (p,p'-DDE), 2,3',4,4',5-pentachlorobiphenyl (PCB118), 2,2',3,4,4',5'-pentachlorobiphenyl (PCB138) and 2,2',4,4',5,5'-pentachlorobiphenyl (PCB153). We determined faeces:plasma concentration ratios (K|), which can be used to estimate C| from measurements of C| for infants/toddlers. For a given chemical, the variation in K| across individuals was considerable (CV from 0.46 to 0.70). Between 5% and 50% of this variation was attributed to short-term intra-individual variability between successive faecal samples. This variability could be reduced by pooling faeces samples over several days. Some of the remaining variability was attributed to longer-term intra-individual variability, which was consistent with previously reported observations of a decrease in K| over the first year of life. The strong correlations between C| and C| demonstrate the promise of using faeces for biomonitoring of these compounds. Future research on the sources of variability in K| could improve the precision and utility of this technique.
• Subjects:
  Child, Preschool Double-Blind Method Environmental Monitoring Environmental Pollutants Feces Female Halogenated Diphenyl Ethers Humans Hydrocarbons, Chlorinated Infant Male

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• Keywords:
  Blood Faeces Infants Non-invasive Bio-monitoring POPs Toddlers
• Source:
  Environ Int. 107:82-88
• Pubmed ID:
  28689110
• Pubmed Central ID:
  PMC5633368
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  107
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:105926ef50d80eb6cafdc2b95367249ff20d74a6d9047ab0e62a4ecde617c289
• Download URL:
  https://stacks.cdc.gov/view/cdc/49026/cdc_49026_DS1.pdf
• File Type:
  [PDF - 454.46 KB ]