Details:

Alternative Title:
Environ Int
Publisher's site:
http://dx.doi.org/10.1016/j.envint.2017.06.019
Personal Author:
Chen, Yiqin ; Sjodin, Andreas ; McLachlan, Michael S. ; English, Karin ; Aylward, Lesa L. ; ... More +
Chen, Yiqin ; Sjodin, Andreas ; McLachlan, Michael S. ; English, Karin ; Aylward, Lesa L. ; Toms, Leisa-Maree L. ; Varghese, Julie ; Sly, Peter D. ; Mueller, Jochen F. Less -
Description:
Early-childhood biomonitoring of persistent organic pollutants (POPs) is challenging due to the logistic and ethical limitations associated with blood sampling. We investigated using faeces as a non-invasive matrix to estimate internal exposure to POPs. The concentrations of selected POPs were measured in matched plasma and faecal samples collected from 20 infants/toddlers (aged 13±4.8months), including a repeat sample time point for 13 infants (~5months apart). We observed higher rates of POP quantification in faeces (2g dry weight) than in plasma (0.5mL). Among the five chemicals that had quantification frequencies over 50% in both matrices, except for HCB, log concentration in faeces (C|) and blood (C|) were correlated (r>0.74, P<0.05) for p.p'-dichlorodiphenyldichloroethylene (p,p'-DDE), 2,3',4,4',5-pentachlorobiphenyl (PCB118), 2,2',3,4,4',5'-pentachlorobiphenyl (PCB138) and 2,2',4,4',5,5'-pentachlorobiphenyl (PCB153). We determined faeces:plasma concentration ratios (K|), which can be used to estimate C| from measurements of C| for infants/toddlers. For a given chemical, the variation in K| across individuals was considerable (CV from 0.46 to 0.70). Between 5% and 50% of this variation was attributed to short-term intra-individual variability between successive faecal samples. This variability could be reduced by pooling faeces samples over several days. Some of the remaining variability was attributed to longer-term intra-individual variability, which was consistent with previously reported observations of a decrease in K| over the first year of life. The strong correlations between C| and C| demonstrate the promise of using faeces for biomonitoring of these compounds. Future research on the sources of variability in K| could improve the precision and utility of this technique.
Subject:
[+]
Article
Blood
Child, Preschool
Double-Blind Method
Environmental Monitoring
Environmental Pollutants
Faeces
Feces
Female
Halogenated Diphenyl Ethers
Humans
Hydrocarbons, Chlorinated
Infant
Infants
Male
Non-invasive Bio-monitoring
POPs
Toddlers

Source:
Environ Int. 107:82-88.
Pubmed ID:
28689110
Pubmed Central ID:
PMC5633368
Document Type:
Journal Article
Funding:
CC999999/ImCDC/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:105926ef50d80eb6cafdc2b95367249ff20d74a6d9047ab0e62a4ecde617c289
File Type:

Supporting Files

• 	NIHMS897951-supplement-Supplemental.docx	docx
  	nihms897951.nxml	xml
  	nihms897951f1.gif	gif
  	nihms897951f1.jpg	jpeg

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