Immediately Dangerous to Life or Health (IDLH) Value Profile: Nitrogen Dioxide (CAS No. 10102-44-0)

Details

• Journal Article:
  National Institute for Occupational Safety and Health
• Personal Author:
  Dotson, G. Scott ; Maier, Andrew ; Parker, Ann ; Haber, Lynn T.
• Description:
  Overview of the IDLH Value for Nitrogen Dioxide IDLH value: 13 ppm (24 mg/m3). Basis for IDLH value: The IDLH value for nitrogen dioxide is based on a LOAEL of 30 ppm for respiratory irritation and severe cough in volunteers following a 70 minute exposure [Henschler et al. 1960]. Duration adjustment resulted in the calculation of a 30-minute equivalent LOAEL of 38 ppm. A composite uncertainty factor of 3 was applied to account for human variability yielding an IDLH value 13 ppm for nitrogen dioxide. 1.2 Purpose This IDLH Value Profile presents (1) a brief summary of technical data associated with acute inhalation exposures to nitrogen dioxide and (2) the rationale behind the immediately dangerous to life or health (IDLH) value for nitrogen dioxide. IDLH values are developed on the basis of scientific rationale and logic outlined in the NIOSH Current Intelligence Bulletin (CIB) 66: Derivation of Immediately Dangerous to Life or Health (IDLH) Values [NIOSH 2013]. As described in CIB 66, NIOSH performs in-depth literature searches to ensure that all relevant data from human and animal studies with acute exposures to the substance are identified. Information included in CIB 66 on the literature search includes pertinent databases, key terms, and guides for evaluating data quality and relevance for the establishment of an IDLH value. The information that is identified in the in-depth literature search is evaluated with general considerations that include description of studies (i.e., species, study protocol, exposure concentration and duration), health endpoint evaluated, and critical effect levels (e.g., NOAELs, LOAELs, and LC50 values). For nitrogen dioxide, the in-depth literature search was conducted through July 2017. [Description provided by NIOSH]
• Subjects:
  Animals Environmental Exposure Hazardous Substances Irritants Laboratories Lung Lung Diseases Maximum Allowable Concentration Nitrogen Dioxide Occupational Exposure Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Sense Organs Threshold Limit Values

  More +
• Keywords:
  Nitrogen dioxide; Respiratory irritants; Respiratory function; Exposure levels; Risk factors; Immediately Dangerous to Life or Health; IDLH; Current intelligence bulletins; Health effects; Health hazards; Irritants; Humans; Animals; Mucous membranes; Pulmonary system; Pulmonary system disorders; Laboratory animals; Toxic effects; Toxins; Nitrogen oxides; Inorganic gases; Nitrogen peroxide
• Source:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2017-202, 2017 Sep; :1-10
• Series:
  NIOSH Numbered Publications
• Subseries:
  Immediately Dangerous to Life or Health (IDLH) Value Profile
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  26 pdf pages
• NIOSHTIC Number:
  nn:20050451
• NTIS Accession Number:
  PB2018-100183
• CAS Registry Number:
  Nitrogen dioxide (CAS RN 10102-44-0)
• Federal Fiscal Year:
  2017
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:28a66d4d09531ef7ec1a3200d3c0e3d359c48e460623b2cded9d0bc39cadbdd27e7ad11e8bcc360c26c4f5a6f8129b9b61e0b83e14a5c991dc697fdd9504cfe5
• Download URL:
  https://stacks.cdc.gov/view/cdc/49019/cdc_49019_DS1.pdf
• File Type:
  [PDF - 386.18 KB ]