Disease Burden of Clostridium difficile Infections in Adults, Hong Kong, China, 2006–2014

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Ho, Jeffery ; Dai, Rudin Z.W. ; Kwong, Thomas N.Y. ; Wang, Xiansong ; Zhang, Lin ; Ip, Margaret ; Chan, Raphael ; Hawkey, Peter M.K. ; Lam, Kelvin L.Y. ; Wong, Martin C.S. ; Tse, Gary ; Chan, Matthew T.V. ; Chan, Francis K.L. ; Yu, Jun ; Ng, Siew C. ; Lee, Nelson ; Wu, Justin C.Y. ; Sung, Joseph J.Y. ; Wu, William K.K. ; Wong, Sunny H.
• Description:
  Cross-sectional studies suggest an increasing trend in incidence and relatively low recurrence rates of Clostridium difficile infections in Asia than in Europe and North America. The temporal trend of C. difficile infection in Asia is not completely understood. We conducted a territory-wide population-based observational study to investigate the burden and clinical outcomes in Hong Kong, China, over a 9-year period. A total of 15,753 cases were identified, including 14,402 (91.4%) healthcare-associated cases and 817 (5.1%) community-associated cases. After adjustment for diagnostic test, we found that incidence increased from 15.41 cases/100,000 persons in 2006 to 36.31 cases/100,000 persons in 2014, an annual increase of 26%. This increase was associated with elderly patients, for whom incidence increased 3-fold over the period. Recurrence at 60 days increased from 5.7% in 2006 to 9.1% in 2014 (p<0.001). Our data suggest the need for further surveillance, especially in Asia, which contains ≈60% of the world's population.
• Subjects:
  Adolescent Adult Aged Aged, 80 And Over Clostridium Difficile Clostridium Infections/epidemiology Clostridium Infections/microbiology Clostridium Infections/mortality Community-Acquired Infections Cross-Sectional Studies Cross Infection/epidemiology Cross Infection/microbiology Cross Infection/mortality Epidemiological Monitoring Female Humans Incidence Male Middle Aged Recurrence Research Survival Analysis

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• Source:
  Emerg Infect Dis. 23(10):1671-1679.
• Pubmed ID:
  28930010
• Pubmed Central ID:
  PMC5621553
• Document Type:
  Journal Article
• Place as Subject:
  Hong Kong
• Location:
  Asia
• Volume:
  23
• Issue:
  10
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:f0a4189132fe6db96ef936c0d77e654dafa6556b707ff115c92b53ec29b06d4d
• Download URL:
  https://stacks.cdc.gov/view/cdc/48993/cdc_48993_DS1.pdf
• File Type:
  [PDF - 723.11 KB ]