Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Mohanty, Madhu Chhanda ; Madkaikar, Manisha Rajan ; Desai, Mukesh ; Taur, Prasad ; Nalavade, Uma Prajwal ; ... More +
Mohanty, Madhu Chhanda ; Madkaikar, Manisha Rajan ; Desai, Mukesh ; Taur, Prasad ; Nalavade, Uma Prajwal ; Sharma, Deepa Kailash ; Gupta, Maya ; Dalvi, Aparna ; Shabrish, Snehal ; Kulkarni, Manasi ; Aluri, Jahnavi ; Deshpande, Jagadish Mohanrao Less -
Description:
Prolonged excretion of poliovirus can occur in immunodeficient patients who receive oral polio vaccine, which may lead to propagation of highly divergent vaccine-derived polioviruses (VDPVs), posing a concern for global polio eradication. This study aimed to estimate the proportion of primary immunodeficient children with enterovirus infection and to identify the long-term polio/nonpolio enterovirus excreters in a tertiary care unit in Mumbai, India. During September 2014-April 2017, 151 patients received diagnoses of primary immunodeficiency (PID). We isolated 8 enteroviruses (3 polioviruses and 5 nonpolio enteroviruses) in cell culture of 105 fecal samples collected from 42 patients. Only 1 patient with severe combined immunodeficiency was identified as a long-term VDPV3 excreter (for 2 years after identification of infection). Our results show that the risk of enterovirus excretion among children in India with PID is low; however, systematic screening is necessary to identify long-term poliovirus excreters until the use of oral polio vaccine is stopped.
Subject:
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Child
Child, Preschool
Enterovirus C, Human
Enterovirus Infections
Feces/virology
Female
Humans
Immunologic Deficiency Syndromes
Male
Poliomyelitis
Poliovirus
Poliovirus Vaccine, Oral
Research
Risk
Virus Shedding/immunology

Source:
Emerg Infect Dis. 23(10):1664-1670.
Pubmed ID:
28930011
Pubmed Central ID:
PMC5621533
Document Type:
Journal Article
Place as Subject:
India
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:f8d8128aedaf5ac4ae4e58630ce29a5d5fd53e8a4e2ee4d794172c86c2c31fe4
File Type:

Supporting Files

• 17-0724.nxml

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