Antimicrobial Drug Prescription and Neisseria gonorrhoeae Susceptibility, United States, 2005–2013

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Kirkcaldy, Robert D. ; Bartoces, Monina G. ; Soge, Olusegun O. ; Riedel, Stefan ; Kubin, Grace ; Del Rio, Carlos ; Papp, John R. ; Hook, Edward W. ; Hicks, Lauri A.
• Description:
  We investigated whether outpatient antimicrobial drug prescribing is associated with Neisseria gonorrhoeae antimicrobial drug susceptibility in the United States. Using susceptibility data from the Gonococcal Isolate Surveillance Project during 2005-2013 and QuintilesIMS data on outpatient cephalosporin, macrolide, and fluoroquinolone prescribing, we constructed multivariable linear mixed models for each antimicrobial agent with 1-year lagged annual prescribing per 1,000 persons as the exposure and geometric mean MIC as the outcome of interest. Multivariable models did not demonstrate associations between antimicrobial drug prescribing and N. gonorrhoeae susceptibility for any of the studied antimicrobial drugs during 2005-2013. Elucidation of epidemiologic factors contributing to resistance, including further investigation of the potential role of antimicrobial drug use, is needed.
• Subjects:
  Anti-Bacterial Agents Cephalosporins Cities Drug Prescriptions Drug Resistance, Multiple, Bacterial Fluoroquinolones Gonorrhea Humans Linear Models Macrolides Microbial Sensitivity Tests Multivariate Analysis Neisseria Gonorrhoeae Research

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• Source:
  Emerg Infect Dis. 23(10):1657-1663.
• Pubmed ID:
  28930001
• Pubmed Central ID:
  PMC5621530
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Location:
  North America
• Volume:
  23
• Issue:
  10
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:905a10bfb016ff828fd563f301cbed5019b9531bc8ae93bd39c32ba9e850c906
• Download URL:
  https://stacks.cdc.gov/view/cdc/48987/cdc_48987_DS1.pdf
• File Type:
  [PDF - 455.26 KB ]