Prenatal phthalate exposures and child temperament at 12 and 24 months

Details

• Alternative Title:
  Neurotoxicology
• Personal Author:
  Singer, Alison B. ; Wolff, Mary S. ; Silva, Manori J. ; Calafat, Antonia M. ; Engel, Stephanie M.
• Description:
  Introduction ; Gestational phthalate exposures have been adversely associated with attention, externalizing, and internalizing behaviors in childhood. Early childhood temperament may be a marker of later behavioral patterns. We therefore sought to determine whether gestational phthalate exposures were associated with infant and toddler temperament. ; Methods ; The Mount Sinai Children’s Environmental Health Study is a prospective cohort study of children born between May 1998 and July 2001 in New York City (N=404). Phthalate metabolites were measured in spot urine samples collected from pregnant women in their third trimester. Child temperament was assessed by parental report at 12-months using the Infant Behavior Questionnaire (IBQ) (N=204) and at 24-months using the Toddler Behavior Assessment Questionnaire (TBAQ) (N=279). We used multiple linear regression to evaluate associations between urinary phthalate metabolites and eleven temperament domains. ; Results ; Phthalate biomarker concentrations were weakly associated with lower gross motor activity levels as well as higher duration of orienting at the 12-month assessment. Mono(3-carboxypropyl) phthalate (MCPP), monobenzyl phthalate (MBzP) and the sum of metabolites of di(2-ethylhexyl) phthalate (ΣDEHP) were associated with lower levels of smiling and laughing at 12 months. At 24-months, social fear and lower pleasure was linked to higher concentrations of MCPP and MBzP, and higher ΣDEHP was weakly associated with increased anger levels at 24-months. ; Conclusions ; Though we observed some weak associations between biomarkers of prenatal exposure to phthalates and temperament at 12- and 24-months, overall phthalates biomarkers were not strongly associated with alterations in temperament.
• Subjects:
  • Anti-Retroviral Agents
  • Breast Feeding
  • Disease Management
  • Female
  • HIV Infections
  • Humans
  • Infectious Disease Transmission, Vertical
  • Learning
  • Malawi
  • Male
  More +
• Keywords:
  • Phthalate
  • Temperament
  • Environmental exposure
  • Infant
  • Toddler
• Source:
  Neurotoxicology. 62:248-257
• Pubmed ID:
  28803130
• Pubmed Central ID:
  PMC5623642
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  62
• Download URL:
  https://stacks.cdc.gov/view/cdc/48497/cdc_48497_DS1.pdf
• File Type:
  [PDF - 538.34 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:3c4b8e3a07a61ec9bc43e7f746f97cd5c33345fcb3b53b1f688eaf11cba37d8ca4091966ffc5c766969fe5ed12240f1c682822d7a1e80b849fce36b573b27656