Details:

Alternative Title:
Physiol Meas
Personal Author:
Specht, Aaron J ; Weisskopf, Marc G ; Nie, Linda Huiling
Specht, Aaron J ; Weisskopf, Marc G ; Nie, Linda Huiling Less -
Description:
Objective

K-shell x-ray fluorescence (KXRF) techniques have been used to identify health effects resulting from exposure to metals for decades, but the equipment is bulky and requires significant maintenance and licensing procedures. A portable x-ray fluorescence (XRF) device was developed to overcome these disadvantages, but introduced a measurement dependency on soft tissue thickness. With recent advances to detector technology, an XRF device utilizing the advantages of both systems should be feasible.

Approach

In this study, we used Monte Carlo simulations to test the feasibility of an XRF device with a high-energy x-ray tube and detector operable at room temperature.

Main Results

We first validated the use of Monte Carlo N-particle transport code (MCNP) for x-ray tube simulations, and found good agreement between experimental and simulated results. Then, we optimized x-ray tube settings and found the detection limit of the high-energy x-ray tube based XRF device for bone lead measurements to be 6.91 μg g−1 bone mineral using a cadmium zinc telluride detector.

Significance

In conclusion, this study validated the use of MCNP in simulations of x-ray tube physics and XRF applications, and demonstrated the feasibility of a high-energy x-ray tube based XRF for metal exposure assessment.


Subject:
[+]
Article
Bone Lead
Exposure Assessment
In Vivo
Lead
Metals
X-ray Fluorescence
XRF

Source:
Physiol Meas. 38(3):575-585.
Pubmed ID:
28169835
Pubmed Central ID:
PMC5617120
Document Type:
Journal Article
Funding:
R21 ES024700/ES/NIEHS NIH HHS/United States ; R21 OH010044/OH/NIOSH CDC HHS/United States
R21 ES024700/ES/NIEHS NIH HHS/United States ; R21 OH010044/OH/NIOSH CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:14f9d44c7c961c962840369fd36fec9bc8f6ef633f33ac0900dffcdffbdc096b
File Type:

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