XRF-measured bone lead (Pb) as a biomarker for Pb exposure and toxicity among children diagnosed with Pb poisoning

Specht, Aaron J.; Lin, Yanfen; Weisskopf, Marc; Yan, Chonghuai; Hu, Howard; Xu, Jian; Nie, Linda H.

doi:10.3109/1354750X.2016.1139183

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XRF-measured bone lead (Pb) as a biomarker for Pb exposure and toxicity among children diagnosed with Pb poisoning

Published Date:

Feb 09 2016

Publisher's site:

http://dx.doi.org/10.3109/1354750X.2016.1139183 New Site Icon

Source:

Biomarkers. 21(4):347-352.

[PDF - 1.01 MB]

Details:

Personal Authors:

Specht, Aaron J. ; Lin, Yanfen ; Weisskopf, Marc ; Yan, Chonghuai ; Hu, Howard ; ... More ▼

Keywords:

[+]

Pubmed ID:

26856822

Pubmed Central ID:

PMC4964874

Description:

Childhood lead (Pb) poisoning remains a global issue, especially in industrial areas. In this study, 115 children with average age 5.7 years were recruited as either patient diagnosed with Pb poisoning or controls at Xinhua Hospital in China. The subjects' bone Pb was measured with a K-shell X-ray fluorescence (KXRF) and a portable X-ray fluorescence (XRF) system. A significant correlation between KXRF bone Pb and blood Pb and portable XRF and KXRF measurements were observed. The half-life of blood-lead was calculated to be 9.96 ± 3.92 d. Our results indicate that bone is a useful biomarker for Pb in children.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

1R21OH010044/OH/NIOSH CDC HHS/United States
R21 ES024700/ES/NIEHS NIH HHS/United States

Supporting Files:

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