XRF-measured bone lead (Pb) as a biomarker for Pb exposure and toxicity among children diagnosed with Pb poisoning

Details

• Alternative Title:
  Biomarkers
• Personal Author:
  Specht, Aaron J. ; Lin, Yanfen ; Weisskopf, Marc ; Yan, Chonghuai ; Hu, Howard ; Xu, Jian ; Nie, Linda H.
• Description:
  Childhood lead (Pb) poisoning remains a global issue, especially in industrial areas. In this study, 115 children with average age 5.7 years were recruited as either patient diagnosed with Pb poisoning or controls at Xinhua Hospital in China. The subjects' bone Pb was measured with a K-shell X-ray fluorescence (KXRF) and a portable X-ray fluorescence (XRF) system. A significant correlation between KXRF bone Pb and blood Pb and portable XRF and KXRF measurements were observed. The half-life of blood-lead was calculated to be 9.96 ± 3.92 d. Our results indicate that bone is a useful biomarker for Pb in children.
• Keywords:
  • In vivo
  • portable
  • X-ray fluorescence
  • Biomarkers
  • Bone and Bones
  • Child
  • Child, Preschool
  • China
  • Environmental Exposure
  • Humans
  More +
• Source:
  Biomarkers. 21(4):347-352
• Pubmed ID:
  26856822
• Pubmed Central ID:
  PMC4964874
• Document Type:
  Journal Article
• Funding:
  P30 ES000002/ES/NIEHS NIH HHSUnited States/ ; R21 ES024700/ES/NIEHS NIH HHSUnited States/ ; R21 OH010044/OH/NIOSH CDC HHSUnited States/ ; 1R21OH010044/OH/NIOSH CDC HHSUnited States/
• Volume:
  21
• Issue:
  4
• Download URL:
  https://stacks.cdc.gov/view/cdc/41077/cdc_41077_DS1.pdf
• File Type:
  [PDF - 1.01 MB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:478db276a83909764ed8ecc0ccbf162b436d52a7991be5d5f35747d4abee4c4e