Phenol Concentrations During Childhood and Subsequent Measures of Adiposity Among Young Girls

Details

• Alternative Title:
  Am J Epidemiol
• Personal Author:
  Deierlein, Andrea L. ; Wolff, Mary S. ; Pajak, Ashley ; Pinney, Susan M. ; Windham, Gayle C. ; Galvez, Maida P. ; Rybak, Michael ; Calafat, Antonia M. ; Kushi, Lawrence H. ; Biro, Frank M. ; Teitelbaum, Susan L.
• Description:
  Phenolic compounds represent a class of environmental chemicals with potentially endocrine-disrupting capabilities. We investigated longitudinal associations between childhood exposure to phenols, from both manmade and natural sources, and subsequent measures of adiposity among girls enrolled in the Breast Cancer and the Environment Research Program between 2004 and 2007. Baseline (ages 6-8 years) urinary concentrations were obtained for creatinine and phenol metabolites: enterolactone, genistein, daidzein, benzophenone-3, bisphenol A, the sum of parabens (methyl, ethyl, and propyl parabens), 2,5-dichlorophenol, and triclosan. Body mass index (weight (kg)/height (m)2), waist circumference, and percent body fat were measured at annual or semiannual examinations through 2015 (n = 1,017). Linear mixed-effects regression was used to estimate how baseline concentrations of phenols (tertile groups) were related to changes in girls' adiposity measurements from ages 7 through 15 years. Enterolactone was inversely associated with body mass index, waist circumference, and percent body fat, while 2,5-dichlorophenol was positively associated with these measurements. A nonmonotonic association was observed for triclosan and girls' adiposity; however, it was due to effect modification by baseline overweight status. Triclosan was positively associated with adiposity only among overweight girls. These results suggest that exposure to specific phenols during childhood may influence adiposity through adolescence.
• Subjects:
  Adiposity Adolescent Article Body Mass Index Child Creatinine Environmental Exposure Female Humans Linear Models Longitudinal Studies Obesity Phenol Phenols San Francisco Social Class

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• Source:
  Am J Epidemiol. 186(5):581-592.
• Pubmed ID:
  28525533
• Pubmed Central ID:
  PMC5600702
• Document Type:
  Journal Article
• Funding:
  U01 ES012770/ES/NIEHS NIH HHS/United States ; U01 ES012800/ES/NIEHS NIH HHS/United States ; P01 ES009584/ES/NIEHS NIH HHS/United States ; UL1 TR001433/TR/NCATS NIH HHS/United States ; U01 ES012771/ES/NIEHS NIH HHS/United States ; P30 ES006096/ES/NIEHS NIH HHS/United States ; P30 ES023515/ES/NIEHS NIH HHS/United States ; T32 HD049311/HD/NICHD NIH HHS/United States ; U01 ES012801/ES/NIEHS NIH HHS/United States ; CC999999/Intramural CDC HHS/United States ; U01 ES019453/ES/NIEHS NIH HHS/United States ; U01 ES019457/ES/NIEHS NIH HHS/United States ; U01 ES019454/ES/NIEHS NIH HHS/United States ; UL1 RR029887/RR/NCRR NIH HHS/United States ; U01 ES019435/ES/NIEHS NIH HHS/United States ; R00 ES023474/ES/NIEHS NIH HHS/United States
• Place as Subject:
  New York ; Ohio
• Volume:
  186
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:33bb9be8c2bc60417c1359900f4f4de5f29db95040fef23b290dfd146bf29b73
• Download URL:
  https://stacks.cdc.gov/view/cdc/48224/cdc_48224_DS1.pdf
• File Type:
  [PDF - 217.80 KB ]