A review of high performance liquid chromatographic-mass spectrometric urinary methods for anticancer drug exposure of healthcare workers

Details

• Alternative Title:
  J Chromatogr B Analyt Technol Biomed Life Sci
• Personal Author:
  Mathias, Patricia I. ; Connor, Thomas H. ; B’Hymer, Clayton
• Description:
  This review describes published high performance liquid chromatography/mass spectrometry (HPLC-MS) methods for the determination of anticancer drugs in human urine as non-invasive tool for monitoring of health care worker exposure to antineoplastic and cytotoxic drugs. HPLC-MS is a sensitive and specific method for analysis of anticancer drugs and their metabolites in biological fluids. In this review, a tabular summary and overview of published HPLC-MS methods are presented, as well as future trends and limitations in this area of research.
• Subjects:
  Anticancer Drugs Antineoplastic Agents Antineoplastic Drug Article Biomarkers Chromatography, High Pressure Liquid Health Personnel Humans Liquid Chromatography Mass Spectrometry Occupational Biomonitoring Occupational Exposure Urinary Biomarker

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• Source:
  J Chromatogr B Analyt Technol Biomed Life Sci. 1060:316-324.
• Pubmed ID:
  28654869
• Pubmed Central ID:
  PMC5585056
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Volume:
  1060
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f99eb9f589b0c0e1d0aeb669f101bb1f17ffffac56dbd5fe8ec13ea7d859d710
• Download URL:
  https://stacks.cdc.gov/view/cdc/48020/cdc_48020_DS1.pdf
• File Type:
  [PDF - 443.93 KB ]