NIOSH skin notation (SK) profiles : tetramethyl lead (TML) [CAS No. 75-74-1].
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NIOSH skin notation (SK) profiles : tetramethyl lead (TML) [CAS No. 75-74-1].

  • Published Date:

    August 2017

  • Series:
    DHHS publication ; no. (NIOSH) 2017-191
  • Language:
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  • Description:
    "No toxicokinetic data were identified that estimated the degree of absorption of TML following dermal exposure; however, a model predicted TML to be absorbed following skin contact. An ALD of 6,203 mg/kg [E.I. du Pont de Nemours and Company 1959, 1991] and a MLD of 4,000 were identified, indicating that TML can be absorbed by the skin but were above the critical dermal LD50 value of 2,000 mg/kg body weight that identifies chemical substances with the potential for acute dermal toxicity. Based on the results of the model prediction, and because virtually identical effects were produced by the oral, cutaneous, and inhalation routes of exposure to TML [Schepers 1964], the potency of the substance was evaluated following repeated or prolonged exposure via other exposure routes (i.e., oral) in animals. TML at very low doses caused liver and neuronal damage in rats in an oral exposure study [Schepers 1964], indicating that the potential exists for dermal exposure to cause similar effects as observed in the oral study. No epidemiological investigations or experimental animal studies were identified that evaluated the potential for TML to cause direct skin effects or skin sensitization. Therefore, on the basis of these assessments, TML is assigned a composite skin notation of SK: SYS. Table 3 summarizes the skin hazard designations for TML previously issued by NIOSH and other organizations. No Globally Harmonized System (GHS) of classification and labeling of chemicals dermal classification for TML was located [European Parliament 2008]." - NIOSHTIC-2 Suggested citation: NIOSH [2017]. NIOSH skin notation profile: Tetramethyl lead. By Hudson NL, Dotson GS. Cincinnati, OH: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publi- cation No. 2017-191. NIOSHTIC no. 20050234
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