Details:

Alternative Title:
Birth Defects Res A Clin Mol Teratol
Personal Author:
Steele, Amy ; Johnson, Jane ; Nance, Amy ; Satterfield, Robert ; Alverson, C.J. ; ... More +
Steele, Amy ; Johnson, Jane ; Nance, Amy ; Satterfield, Robert ; Alverson, C.J. ; Mai, Cara Less -
Description:
Background

Obtaining accurate microcephaly prevalence is important given the recent association between microcephaly and Zika virus. Assessing the quality of data sources can guide surveillance programs as they focus their data collection efforts. The Utah Birth Defect Network (UBDN) has monitored microcephaly by data sources since 2003. The objective of this study was to examine the impact of reporting sources for microcephaly surveillance.

Methods

All reported cases of microcephaly among Utah mothers from 2003 to 2013 were clinically reviewed and confirmed. The UBDN database was linked to state vital records and hospital discharge data for analysis. Reporting sources were analyzed for positive predictive value and sensitivity.

Results

Of the 477 reported cases of microcephaly, 251 (52.6%) were confirmed as true cases. The UBDN identified 94 additional cases that were reported to the surveillance system as another birth defect, but were ultimately determined to be true microcephaly cases. The prevalence for microcephaly based on the UBDN medical record abstraction and clinical review was 8.2 per 10,000 live births. Data sources varied in the number and accuracy of reporting, but a case was more likely to be a true case if identified from multiple sources than from a single source.

Conclusion

While some reporting sources are more likely to identify possible and true microcephaly cases, maintaining a multiple source methodology allows for more complete case ascertainment. Surveillance programs should conduct periodic assessments of data sources to ensure their systems are capturing all possible birth defects cases.


Subjects:
[+]
Article Databases, Factual Disease Notification Epidemiological Monitoring Female Humans Infant, Newborn Male Microcephaly Prevalence Retrospective Studies Zika Virus Zika Virus Infection
Source:
Birth Defects Res A Clin Mol Teratol. 106(11):983-988.
Pubmed ID:
27891786
Pubmed Central ID:
PMC5569316
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Place as Subject:
Utah
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:297fbf0c0c60fb8633952afbc9f9ba937caa02790b97aea967e92e2afbcbc914
Download URL:
https://stacks.cdc.gov/view/cdc/47740/cdc_47740_DS1.pdf
File Type:

Supporting Files

• nihms886248.nxml

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