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Childhood polybrominated diphenyl ether (PBDE) exposure and neurobehavior in children at 8 years
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10 2017
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Source: Environ Res. 158:677-684
[PDF-783.36 KB]
Details:
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Alternative Title:Environ Res
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Personal Author:
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Description:Background
Prenatal polybrominated diphenyl ether (PBDE) exposure has been associated with decrements in IQ and increased attention deficit/hyperactivity disorder related behaviors in children; however, data are limited for the role of postnatal exposures.
Objectives
We investigated the association between a series of childhood PBDE concentrations and Full-Scale Intelligence Quotient (FSIQ) and externalizing problems at 8 years.
Methods
We used data from 208 children in the Health Outcomes and Measures of the Environment (HOME) Study, a prospective pregnancy and birth cohort. Child serum PBDEs were measured at 1, 2, 3, 5, and 8 years; missing serum PBDE concentrations were estimated via multiple imputation. The Wechsler Intelligence Scales for Children-IV and the Behavior Assessment System for Children-2 was used to assess intelligence and externalizing behavior, respectively, in children at 8 years. We used multiple informant models to estimate associations between repeated lipid-adjusted PBDEs and child neurobehavior and to test for windows of susceptibility.
Results
Postnatal exposure to PBDE congeners (-28, -47, -99, -100, and -153) at multiple ages was inversely associated with FSIQ at 8 years. For instance, a 10-fold increase in BDE-153 concentrations at 2, 3, 5, and 8 years were all related to lower FSIQ at age 8 (β for 3 years: −7.7-points, 95% CI −12.5, −2.9; β for 8 years: −5.6-points, 95% CI −10.8, −0.4). Multiple PBDE congeners at 8 years were associated with increased hyperactivity and aggressive behaviors at 8 years.
Conclusions
Postnatal PBDE exposure was associated with decrements in FSIQ and increases in hyperactivity and aggressive behaviors.
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Pubmed ID:28734254
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Pubmed Central ID:PMC5567986
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Volume:158
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