Early Life Bisphenol A Exposure and Neurobehavior at 8 Years of Age: Identifying Windows of Heightened Vulnerability

Details

• Alternative Title:
  Environ Int
• Personal Author:
  Stacy, Shaina L. ; Papandonatos, George D. ; Calafat, Antonia M. ; Chen, Aimin ; Yolton, Kimberly ; Lanphear, Bruce P. ; Braun, Joseph M.
• Description:
  Background ; Early life BPA exposure could affect neurobehavior, but few studies have investigated whether there are developmental periods when the fetus or child is more vulnerable to these potential effects. ; Objectives ; We explored windows of vulnerability to BPA exposure in a multiethnic cohort of 228 mothers and their children from Cincinnati, Ohio. ; Methods ; We measured urinary BPA concentrations at up to two prenatal and six postnatal time points from the 2nd trimester of pregnancy until the child was age 8 years. At age 8 years, we administered the Behavioral Assessment System for Children-2 (BASC-2), Behavior Rating Inventory of Executive Function, and Wechsler Intelligence Scale for Children-IV. We estimated covariate-adjusted differences in composite scores from each instrument using a multiple informant model designed to identify heightened windows of vulnerability. ; Results ; Among all children, there was not strong evidence that the associations between BPA and neurobehavior varied by the timing of exposure (Visit × BPA p-values=0.16). However, child sex modified the associations of repeated BPA measures with BASC-2 scores (Visit × Sex × BPA p-values=0.02–0.23). For example, each 10-fold increase in prenatal BPA was associated with more externalizing behaviors in girls (β=6.2, 95% CI: 0.8, 11.6), but not boys (β=−0.8, 95% CI: −5.0, 3.4). In contrast, a 10-fold increase in 8-year BPA was associated with more externalizing behaviors in boys (β=3.9, 95% CI: 0.6, 7.2), but not girls (β=0.3, 95% CI: −3.5, 4.1). ; Conclusions ; We found that sex-dependent associations between BPA and child neurobehavior may depend on the timing of BPA exposure.
• Subjects:
  • Article
  • Bisphenol A
  • children
  • neurodevelopment
  • epidemiology
  • Benzhydryl Compounds
  • Child
  • Child Behavior
  • Child, Preschool
  • Cohort Studies
  More +
• Source:
  Environ Int. 107:258-265.
• Pubmed ID:
  28764921
• Pubmed Central ID:
  PMC5567845
• Document Type:
  Journal Article
• Funding:
  R00 ES020346/ES/NIEHS NIH HHS/United States ; P01 ES011261/ES/NIEHS NIH HHS/United States ; R01 ES014575/ES/NIEHS NIH HHS/United States ; CC999999/ImCDC/Intramural CDC HHS/United States ; R01 ES020349/ES/NIEHS NIH HHS/United States ; R01 ES024381/ES/NIEHS NIH HHS/United States
• Volume:
  107
• Download URL:
  https://stacks.cdc.gov/view/cdc/47728/cdc_47728_DS1.pdf
• File Type:
  [PDF - 558.06 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:2f8f972d5212d563374077738aaac2e3232f650662cf5ddca72b516d423a43b4