Details:

Alternative Title:
Environ Int
Publisher's site:
http://dx.doi.org/10.1016/j.envint.2017.07.021
Personal Author:
Stacy, Shaina L. ; Papandonatos, George D. ; Calafat, Antonia M. ; Chen, Aimin ; Yolton, Kimberly ; ... More +
Stacy, Shaina L. ; Papandonatos, George D. ; Calafat, Antonia M. ; Chen, Aimin ; Yolton, Kimberly ; Lanphear, Bruce P. ; Braun, Joseph M. ; Less -
Description:
Background Early life BPA exposure could affect neurobehavior, but few studies have investigated whether there are developmental periods when the fetus or child is more vulnerable to these potential effects. Objectives We explored windows of vulnerability to BPA exposure in a multiethnic cohort of 228 mothers and their children from Cincinnati, Ohio. Methods We measured urinary BPA concentrations at up to two prenatal and six postnatal time points from the 2nd trimester of pregnancy until the child was age 8 years. At age 8 years, we administered the Behavioral Assessment System for Children-2 (BASC-2), Behavior Rating Inventory of Executive Function, and Wechsler Intelligence Scale for Children-IV. We estimated covariate-adjusted differences in composite scores from each instrument using a multiple informant model designed to identify heightened windows of vulnerability. Results Among all children, there was not strong evidence that the associations between BPA and neurobehavior varied by the timing of exposure (Visit × BPA p-values=0.16). However, child sex modified the associations of repeated BPA measures with BASC-2 scores (Visit × Sex × BPA p-values=0.02–0.23). For example, each 10-fold increase in prenatal BPA was associated with more externalizing behaviors in girls (β=6.2, 95% CI: 0.8, 11.6), but not boys (β=−0.8, 95% CI: −5.0, 3.4). In contrast, a 10-fold increase in 8-year BPA was associated with more externalizing behaviors in boys (β=3.9, 95% CI: 0.6, 7.2), but not girls (β=0.3, 95% CI: −3.5, 4.1). Conclusions We found that sex-dependent associations between BPA and child neurobehavior may depend on the timing of BPA exposure.
Subject:
[+]
Article
Benzhydryl Compounds
Bisphenol A
Child
Child, Preschool
Child Behavior
Children
Cohort Studies
Endocrine Disruptors
Environmental Monitoring
Environmental Pollutants
Epidemiology
Female
Humans
Infant
Male
Mothers
Neurodevelopment
Phenols
Pregnancy
Prenatal Exposure Delayed Effects
Time Factors

Source:
Environ Int. 107:258-265.
Pubmed ID:
28764921
Pubmed Central ID:
PMC5567845
Document Type:
Journal Article ;
Funding:
R00 ES020346/ES/NIEHS NIH HHS/United States ; P01 ES011261/ES/NIEHS NIH HHS/United States ; R01 ES014575/ES/NIEHS NIH HHS/United States ; CC999999/ImCDC/Intramural CDC HHS/United States ; R01 ES020349/ES/NIEHS NIH HHS/United States ; ... More +
R00 ES020346/ES/NIEHS NIH HHS/United States ; P01 ES011261/ES/NIEHS NIH HHS/United States ; R01 ES014575/ES/NIEHS NIH HHS/United States ; CC999999/ImCDC/Intramural CDC HHS/United States ; R01 ES020349/ES/NIEHS NIH HHS/United States ; R01 ES024381/ES/NIEHS NIH HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:2f8f972d5212d563374077738aaac2e3232f650662cf5ddca72b516d423a43b4
File Type:

Supporting Files

• 	NIHMS896596-supplement.docx	docx
  	nihms896596.nxml	xml
  	nihms896596f1.gif	gif
  	nihms896596f1.jpg	jpeg
  	nihms896596f2.gif	gif
  	nihms896596f2.jpg	jpeg

More +