Racial differences in prostate cancer risk in young HIV-positive and HIV-negative men: a prospective cohort study

Details

• Alternative Title:
  Cancer Causes Control
• Personal Author:
  Dutta, Anupriya ; Uno, Hajime ; Holman, Alex ; Lorenz, David R. ; Gabuzda, Dana
• Description:
  Purpose
  
  African American men have the highest incidence of prostate cancer among ethnic groups, and racial disparity is highest in younger men. Prostate cancer prevalence is rising in HIV-infected men due to improved survival on antiretroviral therapies, yet little is known about racial differences in prostate cancer risk by HIV-infection status and age.
  
  Methods
  
  Prospective cohort study of prostate cancer risk in 2800 HIV-infected and -uninfected men who have sex with men (MSM) ages 40–70 (22% African American) in the Multicenter AIDS Cohort Study from 1996–2010. Poisson regression models were used to examine associations between race or HIV-infection status and prostate cancer risk among men ages 40–70, 40–55, and 56–70.
  
  Results
  
  Among men ages 40–70, incidence rates (IR) per 100,000 person years were 169 among all men and 276 among African American HIV-infected men. Prostate cancer risk was similar by HIV-infection status (IRR 1.0, 95% CI 0.55–1.82), but nearly 3-fold higher in African Americans compared to non-African Americans in adjusted models (IRRs 2.66 and 3.22, 95% CIs 1.36–5.18 and 1.27–8.16 for all or HIV-infected men, respectively). Racial disparity in prostate cancer risk was greatest in African American men ages 40–55 (adjusted IRR 3.31, 95% CI 1.19–9.22). Prostate cancer risk showed associations with family history of prostate cancer (p =0.001), but not heavy smoking, androgen supplement use, or HIV-related factors.
  
  Conclusions
  
  Among MSM, African American HIV-positive and HIV-negative men ages 40–55 have nearly a 3-fold increased risk of young-onset prostate cancer compared to non-African American men, highlighting the need to make informed decisions about screening in this population.
  
  
• Subjects:
  Adult Aged HIV Infections Humans Incidence Male Middle Aged Prospective Studies Prostatic Neoplasms Racial Groups Risk

  More +
• Keywords:
  Cancer Epidemiology Cancer Racial Disparity Cancer Risk HIV-1 Prostate Cancer
• Source:
  Cancer Causes Control. 28(7):767-777
• Pubmed ID:
  28451806
• Pubmed Central ID:
  PMC5557016
• Document Type:
  Journal Article
• Funding:
  U01 AI035042/AI/NIAID NIH HHSUnited States/ ; HHSN261201000140C/CA/NCI NIH HHSUnited States/ ; T32 AI007386/AI/NIAID NIH HHSUnited States/ ; HHSN261201000035C/CA/NCI NIH HHSUnited States/ ; U01 AI035041/AI/NIAID NIH HHSUnited States/ ; UM1 AI035043/AI/NIAID NIH HHSUnited States/ ; U58 DP000795/DP/NCCDPHP CDC HHSUnited States/ ; DP1 DA028994/DA/NIDA NIH HHSUnited States/ ; HHSN261201000035I/CA/NCI NIH HHSUnited States/ ; UL1 TR000424/TR/NCATS NIH HHSUnited States/ ; HHSN261201000034C/CA/NCI NIH HHSUnited States/ ; U58 DP003862/DP/NCCDPHP CDC HHSUnited States/ ; U01 AI035040/AI/NIAID NIH HHSUnited States/ ; U01 AI035039/AI/NIAID NIH HHSUnited States/ ; U01 AI035043/AI/NIAID NIH HHSUnited States/ ; UL1 TR001102/TR/NCATS NIH HHSUnited States/
• Volume:
  28
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:2ba49d687dfe2e34612016547ed72a661934a964495773d5a8645dffcc9bbf6d
• Download URL:
  https://stacks.cdc.gov/view/cdc/47596/cdc_47596_DS1.pdf
• File Type:
  [PDF - 116.33 KB ]