Details:

Alternative Title:
Pediatr Infect Dis J
Personal Author:
Jin, Haoxing ; Demmler-Harrison, Gail J. ; Coats, David K. ; Paysse, Evelyn A. ; Bhatt, Amit ; ... More +
Jin, Haoxing ; Demmler-Harrison, Gail J. ; Coats, David K. ; Paysse, Evelyn A. ; Bhatt, Amit ; Edmond, Jane C. ; Yen, Kimberly G. ; Steinkuller, Paul ; Miller, Jerry ; Less -
Description:
Background Cytomegalovirus (CMV) is the most common congenital viral infection in the United States. Visual and ocular sequelae in adolescents and adults who are congenitally infected with CMV have not been well studied. Better understanding of the long-term visual and ocular sequelae can help with early detection, intervention, and appropriate educational accommodations. Methods This study evaluated 237 (77 symptomatic, 109 asymptomatic, and 51 control) patients who underwent a series of age-appropriate ophthalmologic, audiologic, and neurodevelopmental examinations from 1982 to 2013. The frequency and etiology of visual impairment and other non-ophthalmologic findings were recorded for each patient. Ophthalmologic findings were tabulated and risk factors for abnormalities were analyzed. Results Fourteen of the 77 (18.2%) symptomatic and none of the asymptomatic and control subjects had severe visual impairments (p ≤ 0.006). Moderate visual impairment did not differ between symptomatic and asymptomatic subjects. Three asymptomatic subjects had retinal scars. The most common visual or ocular sequelae in the symptomatic group were strabismus (23.4%), chorioretinal scars (19.5%), cortical visual impairment (14.3%), nystagmus (14.3%), and optic nerve atrophy (11.7%). Three symptomatic patients had delayed visual deterioration due to later occurring retinal disorders: peripheral retinal scar, rhegmatogenous retinal detachment, and Coats’ disease. Conclusion Symptomatic CMV patients experienced more ophthalmologic sequelae and significantly worse visual outcomes than asymptomatic CMV and control patients. Later occurring retinal disorders were found in symptomatic patients, and there is no clear evidence that CMV can reactivate in the retinas of children who were congenitally infected. Major risk factors for severe visual impairment included symptomatic status, optic nerve atrophy, chorioretinitis, cortical visual impairment, and sensorineural hearing loss.
Subject:
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Adolescent
Adult
Article
Birth Weight
Child
Child, Preschool
Chronic Disease
CMV
Congenital Cytomegalovirus
Cytomegalovirus Infections
Eye Infections, Viral
Female
Gestational Age
Humans
Infant
Infant, Newborn
Long-term
Longitudinal Studies
Male
Sequelae
Strabismus
Vision Disorders
Visual
Young Adult

Source:
Pediatr Infect Dis J. 36(9):877-882. ;
Pubmed ID:
28399055
Pubmed Central ID:
PMC5555772
Document Type:
Journal Article ;
Funding:
M01 RR000188/RR/NCRR NIH HHS/United States ; P30 HD024064/HD/NICHD NIH HHS/United States ; U01 IP000419/IP/NCIRD CDC HHS/United States ;
M01 RR000188/RR/NCRR NIH HHS/United States ; P30 HD024064/HD/NICHD NIH HHS/United States ; U01 IP000419/IP/NCIRD CDC HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:1d288efeb9ad9a62ef46767fd3ef3fe01e3dcfe66ad9c38d0992991d9638ed44
File Type:

Supporting Files

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