Long-term Visual and Ocular Sequelae in Patients with Congenital
Cytomegalovirus Infection

Jin, Haoxing; Demmler-Harrison, Gail J.; Coats, David K.; Paysse, Evelyn A.; Bhatt, Amit; Edmond, Jane C.; Yen, Kimberly G.; Steinkuller, Paul; Miller, Jerry

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Long-term Visual and Ocular Sequelae in Patients with Congenital Cytomegalovirus Infection

Published Date:

Sep 2017

Source:

Pediatr Infect Dis J. 36(9):877-882.

Language:

English

[PDF-150.05 KB]

Details:

Alternative Title:

Pediatr Infect Dis J

Personal Author:

Jin, Haoxing ; Demmler-Harrison, Gail J. ; Coats, David K. ; Paysse, Evelyn A. ; Bhatt, Amit ; ... More ▼

Description:

Background

Cytomegalovirus (CMV) is the most common congenital viral infection in the United States. Visual and ocular sequelae in adolescents and adults who are congenitally infected with CMV have not been well studied. Better understanding of the long-term visual and ocular sequelae can help with early detection, intervention, and appropriate educational accommodations.

Methods

This study evaluated 237 (77 symptomatic, 109 asymptomatic, and 51 control) patients who underwent a series of age-appropriate ophthalmologic, audiologic, and neurodevelopmental examinations from 1982 to 2013. The frequency and etiology of visual impairment and other non-ophthalmologic findings were recorded for each patient. Ophthalmologic findings were tabulated and risk factors for abnormalities were analyzed.

Results

Fourteen of the 77 (18.2%) symptomatic and none of the asymptomatic and control subjects had severe visual impairments (p ≤ 0.006). Moderate visual impairment did not differ between symptomatic and asymptomatic subjects. Three asymptomatic subjects had retinal scars. The most common visual or ocular sequelae in the symptomatic group were strabismus (23.4%), chorioretinal scars (19.5%), cortical visual impairment (14.3%), nystagmus (14.3%), and optic nerve atrophy (11.7%). Three symptomatic patients had delayed visual deterioration due to later occurring retinal disorders: peripheral retinal scar, rhegmatogenous retinal detachment, and Coats’ disease.

Conclusion

Symptomatic CMV patients experienced more ophthalmologic sequelae and significantly worse visual outcomes than asymptomatic CMV and control patients. Later occurring retinal disorders were found in symptomatic patients, and there is no clear evidence that CMV can reactivate in the retinas of children who were congenitally infected. Major risk factors for severe visual impairment included symptomatic status, optic nerve atrophy, chorioretinitis, cortical visual impairment, and sensorineural hearing loss.

Subject:

[+]

Pubmed ID:

28399055

Pubmed Central ID:

PMC5555772

Document Type:

Journal Article

Funding:

M01 RR000188/RR/NCRR NIH HHS/United States ; P30 HD024064/HD/NICHD NIH HHS/United States ; U01 IP000419/IP/NCIRD CDC HHS/United States ;

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

Supporting Files:

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