Trends in ART prescription and viral suppression among HIV-positive young adults in care in the United States, 2009–2013

Details

• Alternative Title:
  J Acquir Immune Defic Syndr
• Personal Author:
  Beer, Linda ; Mattson, Christine L. ; Bradley, Heather ; Shouse, R. Luke
• Corporate Authors:
  for the Medical Monitoring Project
• Description:
  Background
  
  Only 13% of HIV-positive young adults are estimated to be virally suppressed and, even among those receiving medical care, HIV-positive young adults are less likely than older adults to take antiretroviral therapy (ART), be adherent, and be virally suppressed. We sought to examine trends in treatment and health outcomes from 2009 to 2013 among HIV-positive young adults (ages 18–24) in care.
  
  Setting
  
  The Medical Monitoring Project (MMP) is a complex sample survey of HIV-infected adults receiving medical care in the United States.
  
  Methods
  
  We used weighted interview and medical record data collected 06/2009-05/2014 to estimate trends in the prevalence of ART prescription, adherence, side effects, single-tablet ART regimens, regular care utilization and viral suppression among young adults.
  
  Results
  
  From 2009 to 2013, there were significant increases in ART prescription (76% to 87%) and the proportion of young adults taking ART who reported taking single-tablet regimens (49% to 62%). There was no significant change in adherence, side effects, or regular care utilization. Although viral suppression at last test did not change (65% at both time periods), the proportion of young adults who were sustainably virally suppressed significantly increased (29% to 46%). Accounting for ART prescription and single-tablet regimens use attenuated the sustained viral suppression trend.
  
  Conclusions
  
  Although the level of viral suppression among young adults in care remains suboptimal, the observed increases in ART prescription and sustained viral suppression may be cause for optimism regarding efforts to improve outcomes for this vulnerable population.
  
  
• Subjects:
  Adolescent Anti-HIV Agents Cross-Sectional Studies Directive Counseling Ethnicity Female HIV Infections Humans Male Medication Adherence Medication Therapy Management Policy Making Prevalence Viral Load Young Adult

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• Source:
  J Acquir Immune Defic Syndr. 76(1):e1-e6
• Pubmed ID:
  28489729
• Pubmed Central ID:
  PMC5552424
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHS/United States
• Place as Subject:
  United States
• Volume:
  76
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:48a9dbfc6fd798a1d470f13bf6206eb34f109bfa2b6270621d7bd316804f8779
• Download URL:
  https://stacks.cdc.gov/view/cdc/47483/cdc_47483_DS1.pdf
• File Type:
  [PDF - 448.72 KB ]