Human Infection with Highly Pathogenic Avian Influenza A(H7N9) Virus, China

Ke, Changwen; Mok, Chris Ka Pun; Zhu, Wenfei; Zhou, Haibo; He, Jianfeng; Guan, Wenda; Wu, Jie; Song, Wenjun; Wang, Dayan; Liu, Jiexiong; Lin, Qinhan; Chu, Daniel Ka Wing; Yang, Lei; Zhong, Nanshan; Yang, Zifeng; Shu, Yuelong; Peiris, Joseph Sriyal Malik

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Human Infection with Highly Pathogenic Avian Influenza A(H7N9) Virus, China

Aug 15 2017
By Ke, Changwen ; Mok, Chris Ka Pun ; Zhu, Wenfei ; ...
Source: Emerg Infect Dis. 23(8):1332-1340.

[PDF-2.04 MB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Ke, Changwen ; Mok, Chris Ka Pun ; Zhu, Wenfei ; Zhou, Haibo ; He, Jianfeng ; ... More +

Ke, Changwen ; Mok, Chris Ka Pun ; Zhu, Wenfei ; Zhou, Haibo ; He, Jianfeng ; Guan, Wenda ; Wu, Jie ; Song, Wenjun ; Wang, Dayan ; Liu, Jiexiong ; Lin, Qinhan ; Chu, Daniel Ka Wing ; Yang, Lei ; Zhong, Nanshan ; Yang, Zifeng ; Shu, Yuelong ; Peiris, Joseph Sriyal Malik Less -
Description:

The recent increase in zoonotic avian influenza A(H7N9) disease in China is a cause of public health concern. Most of the A(H7N9) viruses previously reported have been of low pathogenicity. We report the fatal case of a patient in China who was infected with an A(H7N9) virus having a polybasic amino acid sequence at its hemagglutinin cleavage site (PEVPKRKRTAR/GL), a sequence suggestive of high pathogenicity in birds. Its neuraminidase also had R292K, an amino acid change known to be associated with neuraminidase inhibitor resistance. Both of these molecular features might have contributed to the patient's adverse clinical outcome. The patient had a history of exposure to sick and dying poultry, and his close contacts had no evidence of A(H7N9) disease, suggesting human-to-human transmission did not occur. Enhanced surveillance is needed to determine whether this highly pathogenic avian influenza A(H7N9) virus will continue to spread.
Subjects:

[+]

Amino Acid Sequence Animals Chickens Cytomegalovirus Infections Fatal Outcome Hemagglutinin Glycoproteins, Influenza Virus Humans Influenza, Human Influenza A Virus, H7N9 Subtype Influenza In Birds Male Meat/virology Middle Aged Poultry Diseases Research
Source:

Emerg Infect Dis. 23(8):1332-1340.
Pubmed ID:

28580899
Pubmed Central ID:

PMC5547808
Document Type:

Journal Article
Place as Subject:

China
Location:

Asia
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:fc9dde4d206b0d606e717d2dfb26ec5a38c919f60bde0a35ce5524aa01591dbd
Download URL:

https://stacks.cdc.gov/view/cdc/47417/cdc_47417_DS1.pdf
File Type:

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