Human Infection with Highly Pathogenic Avian Influenza A(H7N9) Virus, China

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Ke, Changwen ; Mok, Chris Ka Pun ; Zhu, Wenfei ; Zhou, Haibo ; He, Jianfeng ; Guan, Wenda ; Wu, Jie ; Song, Wenjun ; Wang, Dayan ; Liu, Jiexiong ; Lin, Qinhan ; Chu, Daniel Ka Wing ; Yang, Lei ; Zhong, Nanshan ; Yang, Zifeng ; Shu, Yuelong ; Peiris, Joseph Sriyal Malik
• Description:
  The recent increase in zoonotic avian influenza A(H7N9) disease in China is a cause of public health concern. Most of the A(H7N9) viruses previously reported have been of low pathogenicity. We report the fatal case of a patient in China who was infected with an A(H7N9) virus having a polybasic amino acid sequence at its hemagglutinin cleavage site (PEVPKRKRTAR/GL), a sequence suggestive of high pathogenicity in birds. Its neuraminidase also had R292K, an amino acid change known to be associated with neuraminidase inhibitor resistance. Both of these molecular features might have contributed to the patient's adverse clinical outcome. The patient had a history of exposure to sick and dying poultry, and his close contacts had no evidence of A(H7N9) disease, suggesting human-to-human transmission did not occur. Enhanced surveillance is needed to determine whether this highly pathogenic avian influenza A(H7N9) virus will continue to spread.
• Subjects:
  Amino Acid Sequence Animals Chickens Cytomegalovirus Infections Fatal Outcome Hemagglutinin Glycoproteins, Influenza Virus Humans Influenza, Human Influenza A Virus, H7N9 Subtype Influenza In Birds Male Meat/virology Middle Aged Poultry Diseases Research

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• Source:
  Emerg Infect Dis. 23(8):1332-1340.
• Pubmed ID:
  28580899
• Pubmed Central ID:
  PMC5547808
• Document Type:
  Journal Article
• Place as Subject:
  China
• Location:
  Asia
• Volume:
  23
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:fc9dde4d206b0d606e717d2dfb26ec5a38c919f60bde0a35ce5524aa01591dbd
• Download URL:
  https://stacks.cdc.gov/view/cdc/47417/cdc_47417_DS1.pdf
• File Type:
  [PDF - 2.04 MB ]