High Infection Rates for Adult Macaques after Intravaginal or Intrarectal Inoculation with Zika Virus

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Haddow, Andrew D. ; Nalca, Aysegul ; Rossi, Franco D. ; Miller, Lynn J. ; Wiley, Michael R. ; Perez-Sautu, Unai ; Washington, Samuel C. ; Norris, Sarah L. ; Wollen-Roberts, Suzanne E. ; Shamblin, Joshua D. ; Kimmel, Adrienne E. ; Bloomfield, Holly A. ; Valdez, Stephanie M. ; Sprague, Thomas R. ; Principe, Lucia M. ; Bellanca, Stephanie A. ; Cinkovich, Stephanie S. ; Lugo-Roman, Luis ; Cazares, Lisa H. ; Pratt, William D. ; Palacios, Gustavo F. ; Bavari, Sina ; Pitt, M. Louise ; Nasar, Farooq
• Description:
  Unprotected sexual intercourse between persons residing in or traveling from regions with Zika virus transmission is a risk factor for infection. To model risk for infection after sexual intercourse, we inoculated rhesus and cynomolgus macaques with Zika virus by intravaginal or intrarectal routes. In macaques inoculated intravaginally, we detected viremia and virus RNA in 50% of macaques, followed by seroconversion. In macaques inoculated intrarectally, we detected viremia, virus RNA, or both, in 100% of both species, followed by seroconversion. The magnitude and duration of infectious virus in the blood of macaques suggest humans infected with Zika virus through sexual transmission will likely generate viremias sufficient to infect competent mosquito vectors. Our results indicate that transmission of Zika virus by sexual intercourse might serve as a virus maintenance mechanism in the absence of mosquito-to-human transmission and could increase the probability of establishment and spread of Zika virus in regions where this virus is not present.
• Subjects:
  Arbovirus Cynomolgus Macaques Expedited High Infection Rates For Adult Macaques After Intravaginal Or Intrarectal Inoculation With Zika Virus Infection Rates Intrarectal Inoculation Intravaginal Inoculation Macaques Mosquitoes Nonhuman Primates Research Rhesus Macaques Sexual Transmission Vector-borne Infections Viruses Zika Virus Zoonoses

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• Source:
  Emerg Infect Dis. 23(8):1274-1281.
• Pubmed ID:
  28548637
• Pubmed Central ID:
  PMC5547779
• Document Type:
  Journal Article
• Volume:
  23
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:9320f3add071ef7c81714af3a04ba2ee6a79fb2472e24328188117f72110c386
• Download URL:
  https://stacks.cdc.gov/view/cdc/47399/cdc_47399_DS1.pdf
• File Type:
  [PDF - 1.20 MB ]