Global Impact of Rotavirus Vaccination on Childhood Hospitalizations and Mortality from Diarrhea

Burnett, Eleanor; Jonesteller, Christine L.; Tate, Jacqueline E.; Yen, Catherine; Parashar, Umesh D.

doi:10.1093/infdis/jix186

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Global Impact of Rotavirus Vaccination on Childhood Hospitalizations and Mortality from Diarrhea

Published Date:

Jun 01 2017

Publisher's site:

http://dx.doi.org/10.1093/infdis/jix186 New Site Icon

Source:

J Infect Dis. 215(11):1666-1672.

[PDF-2.27 MB]

Details:

Personal Authors:

Burnett, Eleanor ; Jonesteller, Christine L. ; Tate, Jacqueline E. ; Yen, Catherine ; Parashar, Umesh D. ;

Keywords:

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Pubmed ID:

28430997

Pubmed Central ID:

PMC5543929

Description:

In 2006, 2 rotavirus vaccines were licensed. We summarize the impact of rotavirus vaccination on hospitalizations and deaths from rotavirus and all-cause acute gastroenteritis (AGE) during the first 10 years since vaccine licensure, including recent evidence from countries with high child mortality. We used standardized guidelines (PRISMA) to identify observational evaluations of rotavirus vaccine impact among children <5 years of age that presented at least 12 months of pre- and post-vaccine introduction surveillance data. We identified 57 articles from 27 countries. Among children <5 years of age, the median percentage reduction in AGE hospitalizations was 38% overall and 41%, 30%, and 46% in countries with low, medium, and high child mortality, respectively. Hospitalizations and emergency department visits due to rotavirus AGE were reduced by a median of 67% overall and 71%, 59%, and 60% in countries with low, medium, and high child mortality, respectively. Implementation of rotavirus vaccines has substantially decreased hospitalizations from rotavirus and all-cause AGE.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

CC999999/Intramural CDC HHS/United States

Main Document Checksum:

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Supporting Files:

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November 12, 2019