Details:

Alternative Title:
J Infect Dis
Publisher's site:
http://dx.doi.org/10.1093/infdis/jix186
Personal Author:
Burnett, Eleanor ; Jonesteller, Christine L. ; Tate, Jacqueline E. ; Yen, Catherine ; Parashar, Umesh D. ;
Burnett, Eleanor ; Jonesteller, Christine L. ; Tate, Jacqueline E. ; Yen, Catherine ; Parashar, Umesh D. ; Less -
Description:
In 2006, 2 rotavirus vaccines were licensed. We summarize the impact of rotavirus vaccination on hospitalizations and deaths from rotavirus and all-cause acute gastroenteritis (AGE) during the first 10 years since vaccine licensure, including recent evidence from countries with high child mortality. We used standardized guidelines (PRISMA) to identify observational evaluations of rotavirus vaccine impact among children <5 years of age that presented at least 12 months of pre- and post-vaccine introduction surveillance data. We identified 57 articles from 27 countries. Among children <5 years of age, the median percentage reduction in AGE hospitalizations was 38% overall and 41%, 30%, and 46% in countries with low, medium, and high child mortality, respectively. Hospitalizations and emergency department visits due to rotavirus AGE were reduced by a median of 67% overall and 71%, 59%, and 60% in countries with low, medium, and high child mortality, respectively. Implementation of rotavirus vaccines has substantially decreased hospitalizations from rotavirus and all-cause AGE.
Subject:
[+]
Article
Child, Preschool
Diarrhea
Emergency Service, Hospital
Gastroenteritis
Hospitalization
Humans
Infant
Infant, Newborn
Rotavirus
Rotavirus Infections
Rotavirus Vaccine
Rotavirus Vaccines
Vaccination
Rotavirus

Source:
J Infect Dis. 215(11):1666-1672.
Pubmed ID:
28430997
Pubmed Central ID:
PMC5543929
Document Type:
Journal Article ;
Funding:
CC999999/Intramural CDC HHS/United States ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:2b45f441544fcf843e681537bd8c2aed74267433c946a757603966f69029415d
File Type:

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