Global Impact of Rotavirus Vaccination on Childhood Hospitalizations and Mortality from Diarrhea

Burnett, Eleanor; Jonesteller, Christine L.; Tate, Jacqueline E.; Yen, Catherine; Parashar, Umesh D.

doi:10.1093/infdis/jix186

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Global Impact of Rotavirus Vaccination on Childhood Hospitalizations and Mortality from Diarrhea

Published Date:

Jun 01 2017

Publisher's site:

http://dx.doi.org/10.1093/infdis/jix186 New Site Icon

Source:

J Infect Dis. 215(11):1666-1672.

[PDF-2.27 MB]

Details:

Alternative Title:

J Infect Dis

Personal Author:

Burnett, Eleanor ; Jonesteller, Christine L. ; Tate, Jacqueline E. ; Yen, Catherine ; Parashar, Umesh D. ;

Description:

In 2006, 2 rotavirus vaccines were licensed. We summarize the impact of rotavirus vaccination on hospitalizations and deaths from rotavirus and all-cause acute gastroenteritis (AGE) during the first 10 years since vaccine licensure, including recent evidence from countries with high child mortality. We used standardized guidelines (PRISMA) to identify observational evaluations of rotavirus vaccine impact among children <5 years of age that presented at least 12 months of pre- and post-vaccine introduction surveillance data. We identified 57 articles from 27 countries. Among children <5 years of age, the median percentage reduction in AGE hospitalizations was 38% overall and 41%, 30%, and 46% in countries with low, medium, and high child mortality, respectively. Hospitalizations and emergency department visits due to rotavirus AGE were reduced by a median of 67% overall and 71%, 59%, and 60% in countries with low, medium, and high child mortality, respectively. Implementation of rotavirus vaccines has substantially decreased hospitalizations from rotavirus and all-cause AGE.

Subject:

[+]

Pubmed ID:

28430997

Pubmed Central ID:

PMC5543929

Document Type:

Journal Article

Funding:

CC999999/Intramural CDC HHS/United States

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

Supporting Files:

	nihms886201f4.gif	image/gif
	nihms886201f4.jpg	image/jpeg
	nihms886201f5.gif	image/gif
	nihms886201f5.jpg	image/jpeg
	nihms886201f6.gif	image/gif
	nihms886201f6.jpg	image/jpeg
	nihms886201f7.gif	image/gif
	nihms886201f7.jpg	image/jpeg
	NIHMS886201-supplement-Table_1.docx	application/vnd.openxmlformats-officedocument.wordprocessingml.document
	nihms886201.nxml	text/xml
	nihms886201f1.gif	image/gif
	nihms886201f1.jpg	image/jpeg
	nihms886201f2.gif	image/gif
	nihms886201f2.jpg	image/jpeg
	nihms886201f3.gif	image/gif
	nihms886201f3.jpg	image/jpeg

No Related Documents.

You May Also Like:

Impact of pentavalent rotavirus vaccine against severe rotavirus diarrhoea in The Gambia

Personal Author:

Sanneh, Bakary; Sey, Alhagie Papa; Shah, Minesh; Tate, Jacqueline; Sonko, Mariama; Jagne, Sheriffo; Jarju, ModouLamin; Sowe, Dawda; Taal, Makie; Cohen, Adam; Parashar, Umesh; Mwenda, Jason M.;

Published Date:

March 12 2018

Source:

Vaccine. 36(47):7179-7184

Description:

Introduction:Rotavirus vaccines protect against the leading cause of severe childhood diarrhoea, and have been introduced in many low-income African countries. The Gambia introduced Rotateq® (RV5) into their national immunization program in 2013. We...

File Type:

[PDF - 678.12 KB]
Rotavirus vaccines

Personal Author:

Yen, Catherine; Tate, Jacqueline E.; Hyde, Terri B.; Cortese, Margaret M.; Lopman, Benjamin A.; Jiang, Baoming; Glass, Roger I.; Parashar, Umesh D.;

Published Date:

Apr 22 2014

Source:

Hum Vaccin Immunother. 10(6):1436-1448.

Description:

Rotavirus is the leading cause of severe diarrhea among children<5 years worldwide. Currently licensed rotavirus vaccines have been efficacious and effective, with many countries reporting substantial declines in diarrheal and rotavirus-specific morb...

File Type:

[PDF - 958.05 KB]
Rotavirus Vaccines: Effectiveness, Safety and Future Directions

Personal Author:

Burnett, Eleanor; Parashar, Umesh; Tate, Jacqueline;

Published Date:

Jun 2018

Source:

Paediatr Drugs. 20(3):223-233

Description:

Rotavirus is the leading cause of diarrheal death among children < 5 years old worldwide, estimated to have caused ~ 215,000 deaths in 2013. Prior to rotavirus vaccine implementation, > 65% of children had at least one rotavirus diarrhea illne...

File Type:

[PDF - 484.03 KB]
Removing the Age Restrictions for Rotavirus Vaccination: A Benefit-Risk Modeling Analysis

Personal Author:

Patel, Manish M.; Clark, Andrew D.; Sanderson, Colin F. B.; Tate, Jacqueline; Parashar, Umesh D.;

Published Date:

Oct 23 2012

Source:

PLoS Med. 2012; 9(10).

Description:

BackgroundTo minimize potential risk of intussusception, the World Health Organization (WHO) recommended in 2009 that rotavirus immunization should be initiated by age 15 weeks and completed before 32 weeks. These restrictions could adversely impact ...

File Type:

[PDF - 762.04 KB]
Reduction in Diarrhea- and Rotavirus-related Healthcare Visits among Children <5 Years of Age Following National Rotavirus Vaccine Introduction in Zimbabwe

Personal Author:

Mujuru, Hilda A.; Yen, Catherine; Nathoo, Kusum J.; Gonah, Nhamo A.; Ticklay, Ismail; Mukaratirwa, Arnold; Berejena, Chipo; Tapfumanei, Ottias; Chindedza, Kenneth; Rupfutse, Maxwell; Weldegebriel, Goitom; Mwenda, Jason M.; Burnett, Eleanor; Tate, Jacqueline E.; Parashar, Umesh D.; Manangazira, Portia;

Published Date:

Oct 2017

Source:

Pediatr Infect Dis J. 36(10):995-999.

Description:

In Zimbabwe, rotavirus accounted for 41%-56% of acute diarrhea hospitalizations before rotavirus vaccine introduction in 2014. We evaluated rotavirus vaccination impact on acute diarrhea- and rotavirus-related healthcare visits in children.|We examin...

File Type:

[PDF - 211.76 KB]