Welcome to CDC stacks | Models of Toxicity of Diacetyl and Alternative Diones - 47325 | CDC Public Access
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
Clear All Simple Search
Advanced Search
Models of Toxicity of Diacetyl and Alternative Diones
  • Published Date:
    Feb 21 2017
  • Source:
    Toxicology. 388:15-20.

Public Access Version Available on: August 01, 2018 information icon
Please check back on the date listed above.
  • Pubmed ID:
  • Pubmed Central ID:
  • Description:
    Diacetyl (DA; 2,3-butanedione), with the chemical formula (CH3CO)2 is a volatile organic compound with a deep yellow color and a strong buttery flavor and aroma. These properties have made DA a particularly useful and common food flavoring ingredient. However, because of this increased occupational use, workers can be exposed to high vapor concentrations in the workplace. Despite being listed by the USFDA to be 'generally regarded as safe' (GRAS), multiple lines of evidence suggest that exposure to high concentrations of DA vapor causes long-term impairments in lung function with lung function testing indicating evidence of either restrictive or obstructive airway narrowing in affected individuals. A growing number of pre-clinical studies have now addressed the short and long-term toxicity associated with DA exposure providing further insight into the toxicity of DA and related diones. This review summarizes these observations.

  • Document Type:
  • Collection(s):
  • Funding:
    R21 OH010490/OH/NIOSH CDC HHS/United States
  • Supporting Files:
    No Additional Files
No Related Documents.
You May Also Like: