Novel Retinal Lesion in Ebola Survivors, Sierra Leone, 2016

Steptoe, Paul J.; Scott, Janet T.; Baxter, Julia M.; Parkes, Craig K.; Dwivedi, Rahul; Czanner, Gabriela; Vandy, Matthew J.; Momorie, Fayiah; Fornah, Alimamy D.; Komba, Patrick; Richards, Jade; Sahr, Foday; Beare, Nicholas A.V.; Semple, Malcolm G.

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Novel Retinal Lesion in Ebola Survivors, Sierra Leone, 2016

Supporting Files Public Domain

Jul 2017
By Steptoe, Paul J. ; Scott, Janet T. ; Baxter, Julia M. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Steptoe, Paul J. ; Scott, Janet T. ; Baxter, Julia M. ; Parkes, Craig K. ; Dwivedi, Rahul ; Czanner, Gabriela ; Vandy, Matthew J. ; Momorie, Fayiah ; Fornah, Alimamy D. ; Komba, Patrick ; Richards, Jade ; Sahr, Foday ; Beare, Nicholas A.V. ; Semple, Malcolm G.
Description:

We conducted a case-control study in Freetown, Sierra Leone, to investigate ocular signs in Ebola virus disease (EVD) survivors. A total of 82 EVD survivors with ocular symptoms and 105 controls from asymptomatic civilian and military personnel and symptomatic eye clinic attendees underwent ophthalmic examination, including widefield retinal imaging. Snellen visual acuity was <6/7.5 in 75.6% (97.5% CI 63%-85.7%) of EVD survivors and 75.5% (97.5% CI 59.1%-87.9%) of controls. Unilateral white cataracts were present in 7.4% (97.5% CI 2.4%-16.7%) of EVD survivors and no controls. Aqueous humor from 2 EVD survivors with cataract but no anterior chamber inflammation were PCR-negative for Zaire Ebola virus, permitting cataract surgery. A novel retinal lesion following the anatomic distribution of the optic nerve axons occurred in 14.6% (97.5% CI 7.1%-25.6%) of EVD survivors and no controls, suggesting neuronal transmission as a route of ocular entry.
Subjects:

Adult Case-Control Studies Ebolavirus Female Hemorrhagic Fever, Ebola/Complications Hemorrhagic Fever, Ebola/Epidemiology Hemorrhagic Fever, Ebola/History Hemorrhagic Fever, Ebola/Virology History, 21St Century Humans Male Ophthalmoscopes Population Surveillance Prevalence Retinal Diseases/Diagnosis Retinal Diseases/Epidemiology Retinal Diseases/Etiology Severity Of Illness Index Survivors Visual Acuity Young Adult
Source:

Emerg Infect Dis. 23(7):1102-1109.
Pubmed ID:

28628441
Pubmed Central ID:

PMC5512503
Document Type:

Journal Article
Place as Subject:

Sierra Leone
Volume:

23
Issue:

7
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:d0961f435f435c2d44ab3473b2555d49182abed5de959f960c2726704d8be5e8
Download URL:

https://stacks.cdc.gov/view/cdc/46754/cdc_46754_DS1.pdf
File Type:

[PDF - 1.52 MB ]

File Language:

English

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