Clonal Clusters and Virulence Factors of Group C and G Streptococcus Causing Severe Infections, Manitoba, Canada, 2012–2014

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Lother, Sylvain A. ; Demczuk, Walter ; Martin, Irene ; Mulvey, Michael ; Dufault, Brenden ; Lagacé-Wiens, Philippe ; Keynan, Yoav
• Description:
  The incidence of group C and G Streptococcus (GCGS) bacteremia, which is associated with severe disease and death, is increasing. We characterized clinical features, outcomes, and genetic determinants of GCGS bacteremia for 89 patients in Winnipeg, Manitoba, Canada, who had GCGS bacteremia during 2012-2014. Of the 89 patients, 51% had bacteremia from skin and soft tissue, 70% had severe disease features, and 20% died. Whole-genome sequencing analysis was performed on isolates derived from 89 blood samples and 33 respiratory sample controls: 5 closely related genetic lineages were identified as being more likely to cause invasive disease than non-clade isolates (83% vs. 57%, p = 0.002). Virulence factors cbp, fbp, speG, sicG, gfbA, and bca clustered clonally into these clades. A clonal distribution of virulence factors may account for severe and fatal cases of bacteremia caused by invasive GCGS.
• Subjects:
  Adolescent Adult Aged Aged, 80 And Over Child Child, Preschool Cluster Analysis Comorbidity Female Genome, Bacterial History, 21St Century Humans Infant Infant, Newborn Male Middle Aged Multilocus Sequence Typing Phylogeny Polymorphism, Single Nucleotide Retrospective Studies Severity Of Illness Index Streptococcal Infections/Diagnosis Streptococcal Infections/Epidemiology Streptococcal Infections/History Streptococcal Infections/Microbiology Streptococcus Virulence Factors Whole Genome Sequencing Young Adult

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• Source:
  Emerg Infect Dis. 23(7):1079-1088.
• Pubmed ID:
  28628457
• Pubmed Central ID:
  PMC5512470
• Document Type:
  Journal Article
• Genre:
  Historical Article
• Place as Subject:
  Manitoba, Canada
• Location:
  North America
• Volume:
  23
• Issue:
  7
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:a3a08eb30563317082686ecc73ccdcb38ab5c388decdbc74aa7aec05ed2ce8ca
• Download URL:
  https://stacks.cdc.gov/view/cdc/46750/cdc_46750_DS1.pdf
• File Type:
  [PDF - 3.21 MB ]