Pneumonia prevention: Cost-effectiveness analyses of two vaccines among refugee children aged under two years, Haemophilus influenzae type b-containing and pneumococcal conjugate vaccines, during a humanitarian emergency, Yida camp, South Sudan

Details

• Alternative Title:
  Vaccine
• Personal Author:
  Gargano, Lisa M. ; Hajjeh, Rana ; Cookson, Susan T.
• Description:
  By September 2013, war between Sudan and South Sudan resulted in >70,000 Sudanese refugees and high pneumonia incidence among the 20,000 refugees in Yida camp, South Sudan. Using Médecins Sans Frontières (MSF)-provided data and modifying our decision-tree models, we estimated if administering Haemophilus influenzae type b (Hib)-containing (pentavalent vaccine, also with diphtheria pertussis and tetanus [DPT] and hepatitis B) and pneumococcal conjugate (PCV) vaccines were cost-effective against hospitalized pneumonia. Among children <2years old, compared with no vaccination, one- and two-doses of combined Hib-containing and PCV would avert an estimated 118 and 125 pneumonia cases, and 8.5 and 9.1 deaths, respectively. The cost per Disability-Adjusted-Life-Year averted for administering combined one- and two-doses was US$125 and US$209, respectively. MSF demonstrated that it was possible to administer these vaccines during an emergency and our analysis found it was highly cost-effective, even with just one-dose of either vaccine. Despite unknown etiology, there is strong field and now economic rationale for administering Hib and PCV during at least one humanitarian emergency.
• Subjects:
  Diphtheria-Tetanus-Pertussis Vaccine Haemophilus Vaccines Hepatitis B Vaccines Humans Infant Infant, Newborn Pneumococcal Vaccines Pneumonia, Bacterial Refugees Vaccines, Conjugate
• Source:
  Vaccine. 35(3):435-442.
• Pubmed ID:
  27989625
• Pubmed Central ID:
  PMC5497221
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Place as Subject:
  South Sudan
• Volume:
  35
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:8047a7ce49c4f91b27d5573b4b9a80dcff5f8ede163a4ff594f5159c45a8282a
• Download URL:
  https://stacks.cdc.gov/view/cdc/46669/cdc_46669_DS1.pdf
• File Type:
  [PDF - 603.45 KB ]