Levels of intracellular phosphorylated tenofovir and emtricitabine correlate with natural substrate concentrations in peripheral blood mononuclear cells of persons prescribed daily oral Truvada™ for HIV pre-exposure prophylaxis

Details

• Alternative Title:
  J Acquir Immune Defic Syndr
• Personal Author:
  Haaland, Richard E. ; Holder, Angela ; Pau, Chou-Pong ; Swaims-Kohlmeier, Alison ; Dawson, Carolyn ; Smith, Dawn K. ; Segolodi, Tebogo M. ; Thigpen, Michael C. ; Paxton, Lynn A. ; Parsons, Teresa L. ; Hendrix, Craig W. ; Hart, Clyde E.
• Subjects:
  Adult Article CD4-Positive T-Lymphocytes Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination Female HIV Infections HIV Reverse Transcriptase Humans Lymphocyte Activation Male Phosphorylation Pre-Exposure Prophylaxis Reverse Transcriptase Inhibitors Substrate Specificity Viral Load

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• Source:
  J Acquir Immune Defic Syndr. 75(3):e86-e88.
• Pubmed ID:
  28225438
• Pubmed Central ID:
  PMC5472483
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHS/United States
• Volume:
  75
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f07a29d2a641faaaeb6b4c96af6b38c75ebadc8b1a9f05a192ad71f60957a384
• Download URL:
  https://stacks.cdc.gov/view/cdc/46248/cdc_46248_DS1.pdf
• File Type:
  [PDF - 389.37 KB ]