Genomic biomarkers of prenatal intrauterine inflammation in umbilical cord tissue predict later life neurological outcomes

Details

• Alternative Title:
  PLoS One
• Personal Author:
  Tilley, Sloane K. ; Joseph, Robert M. ; Kuban, Karl C. K. ; Dammann, Olaf U. ; O’Shea, T. Michael ; Fry, Rebecca C.
• Description:
  Background
  
  Preterm birth is a major risk factor for neurodevelopmental delays and disorders. This study aimed to identify genomic biomarkers of intrauterine inflammation in umbilical cord tissue in preterm neonates that predict cognitive impairment at 10 years of age.
  
  Study design
  
  Genome-wide messenger RNA (mRNA) levels from umbilical cord tissue were obtained from 43 neonates born before 28 weeks of gestation. Genes that were differentially expressed across four indicators of intrauterine inflammation were identified and their functions examined. Exact logistic regression was used to test whether expression levels in umbilical cord tissue predicted neurocognitive function at 10 years of age.
  
  Results
  
  Placental indicators of inflammation were associated with changes in the mRNA expression of 445 genes in umbilical cord tissue. Transcripts with decreased expression showed significant enrichment for biological signaling processes related to neuronal development and growth. The altered expression of six genes was found to predict neurocognitive impairment when children were 10 years old These genes include two that encode for proteins involved in neuronal development.
  
  Conclusion
  
  Prenatal intrauterine inflammation is associated with altered gene expression in umbilical cord tissue. A set of six of the differentially expressed genes predict cognitive impairment later in life, suggesting that the fetal environment is associated with significant adverse effects on neurodevelopment that persist into later childhood.
  
  
• Subjects:
  Adolescent Adult Child Cognition Disorders Female Fetal Diseases Gene Expression Regulation Genetic Markers Humans Infant, Newborn Infant, Premature Inflammation Pregnancy RNA, Messenger Transcriptome Umbilical Cord Young Adult

  More +
• Source:
  PLoS One. 2017; 12(5).
• Pubmed ID:
  28493900
• Pubmed Central ID:
  PMC5426658
• Document Type:
  Journal Article
• Funding:
  T42 OH008673/OH/NIOSH CDC HHS/United States ; UG3 OD023348/OD/NIH HHS/United States ; R01 ES019315/ES/NIEHS NIH HHS/United States ; U01 NS040069/NS/NINDS NIH HHS/United States ; P42 ES005948/ES/NIEHS NIH HHS/United States
• Volume:
  12
• Issue:
  5
• NIOSHTIC Number:
  nn:20049838
• Collection(s):
  CDC Public Access National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:33a15cbaadc0879bbf52dcf0694beac86215b885b1cab579f26297e51e1426c128fdf531f20b7baa52a8841222553130b60ac9f34c8bbb13898c8b79f8020c6f
• Download URL:
  https://stacks.cdc.gov/view/cdc/46230/cdc_46230_DS1.pdf
• File Type:
  [PDF - 1.24 MB ]