Interaction of marijuana and alcohol on fatal motor vehicle crash risk: a case-control study

Details

• Alternative Title:
  Inj Epidemiol
• Personal Author:
  Chihuri, Stanford ; Li, Guohua ; Chen, Qixuan
• Description:
  Background ; Concurrent use of marijuana and alcohol in drivers is of increasing concern but its role in crash causation has not been well understood. ; Methods ; Using a case-control design, we assessed the individual and joint effects of marijuana and alcohol use on fatal crash risk. Cases (n = 1944) were drivers fatally injured in motor vehicle crashes in the United States at specific times in 2006, 2007 and 2008. Controls (n = 7719) were drivers who participated in the 2007 National Roadside Survey of Alcohol and Drug Use by Drivers. ; Results ; Overall, cases were significantly more likely than controls to test positive for marijuana (12.2% vs. 5.9%, p < 0.0001), alcohol (57.8% vs. 7.7%, p < 0.0001) and both marijuana and alcohol (8.9% vs. 0.8%, p < 0.0001). Compared to drivers testing negative for alcohol and marijuana, the adjusted odds ratios of fatal crash involvement were 16.33 95% confidence interval (CI): 14.23, 18.75 for those testing positive for alcohol and negative for marijuana, 1.54 (95% CI: 1.16, 2.03) for those testing positive for marijuana and negative for alcohol, and 25.09 (95% CI: 17.97, 35.03) for those testing positive for both alcohol and marijuana. ; Conclusions ; Alcohol use and marijuana use are each associated with significantly increased risks of fatal crash involvement. When alcohol and marijuana are used together, there exists a positive synergistic effect on fatal crash risk on the additive scale.
• Subjects:
  • Accidents
  • Alcohol
  • Cannabis
  • Case-Control Studies
  • Drug Interactions
  • Motor Vehicles
  • Safety
• Source:
  Inj Epidemiol. 4.
• Pubmed ID:
  28286930
• Pubmed Central ID:
  PMC5357617
• Document Type:
  Text
• Funding:
  R49 CE002096/CE/NCIPC CDC HHS/United States
• Genre:
  Journal Article
• Volume:
  4
• Download URL:
  https://stacks.cdc.gov/view/cdc/46224/cdc_46224_DS1.pdf
• File Type:
  [PDF - 440.12 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:de3b4f74ae55c4c1c781ce37ad38ee8081089e39d23162b54d7a45680a0c98d947f3ad8082d100dd0cc0cf3bab79e516a4c6686b6f12e41ffb02eb6cf91b9ed5