Details:

Alternative Title:
Clin Infect Dis
Personal Author:
Higdon, Melissa M. ; Hammitt, Laura L. ; Deloria Knoll, Maria ; Baggett, Henry C. ; Brooks, W. Abdullah ; ... More +
Higdon, Melissa M. ; Hammitt, Laura L. ; Deloria Knoll, Maria ; Baggett, Henry C. ; Brooks, W. Abdullah ; Howie, Stephen R. C. ; Kotloff, Karen L. ; Levine, Orin S. ; Madhi, Shabir A. ; Murdoch, David R. ; Scott, J. Anthony G. ; Thea, Donald M. ; Driscoll, Amanda J. ; Karron, Ruth A. ; Park, Daniel E. ; Prosperi, Christine ; Zeger, Scott L. ; O’Brien, Katherine L. ; Feikin, Daniel R. Less -
Corporate Authors:
for the PERCH Study Group O’BrienKatherine L.LevineOrin S.KnollMaria DeloriaFeikinDaniel R.DeLucaAndrea N.DriscollAmanda J.FuWeiHammittLaura L.HigdonMelissa M.KaguciaE. WangeciKarronRuth A.LiMengyingParkDaniel E.ProsperiChristineWuZhenkeZegerScott L.WatsonNora L.CrawleyJaneMurdochDavid R.BrooksW. AbdullahEndtzHubert P.ZamanKhalequGoswamiDoliHossainLokmanJahanYasminAshrafHasanHowieStephen R. C.EbrukeBernard E.AntonioMartinMcLellanJessicaMachukaEuniceShamsulArifinZamanSyed M.A.MackenzieGrantScottJ. Anthony G.AworiJuliet O.MorpethSusan C.KamauAliceKazunguSidiKotloffKaren L.TapiaMilagritos D.SowSamba O.SyllaMamadouTambouraBoubouOnwuchekwaUmaKouroumaNanaToureAliouMadhiShabir A.MooreDavid P.AdrianPeter V.BaillieVicky L.KuwandaLocadiahMudauAzwifarwiGroomeMichelle J.BaggettHenry C.ThamthitiwatSomsakMaloneySusan A.BunthiCharatdaoRhodesJuliaSawatwongPongpunAkarasewiPasakornTheaDonald M.MwananyandaLawrenceChipetaJamesSeidenbergPhilMwansaJameswa SomweSomweKwendaGeoffrey
Description:
Many pneumonia etiology case-control studies exclude controls with respiratory illness from enrollment or analyses. Herein we argue that selecting controls regardless of respiratory symptoms provides the least biased estimates of pneumonia etiology. We review 3 reasons investigators may choose to exclude controls with respiratory symptoms in light of epidemiologic principles of control selection and present data from the Pneumonia Etiology Research for Child Health (PERCH) study where relevant to assess their validity. We conclude that exclusion of controls with respiratory symptoms will result in biased estimates of etiology. Randomly selected community controls, with or without respiratory symptoms, as long as they do not meet the criteria for case-defining pneumonia, are most representative of the general population from which cases arose and the least subject to selection bias.
Subject:
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Control Selection
PERCH
Pneumonia Etiology
Respiratory Symptoms
Selection Bias.
Supplement Article

Source:
Clin Infect Dis. 2017; 64(Suppl 3):S205-S212.
Pubmed ID:
28575354
Pubmed Central ID:
PMC5447853
Document Type:
Journal Article
Collection(s):
CDC Public Access
Main Document Checksum:
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urn:sha256:18148394587a342500b978529e0f38b444b8674beac6d2bbf0d825c74e2326ce
File Type:

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