Details:

Alternative Title:
Arthritis Rheumatol
Personal Author:
Qin, Jin ; Barbour, Kamil E. ; Murphy, Louise B. ; Nelson, Amanda E. ; Schwartz, Todd A. ; ... More +
Qin, Jin ; Barbour, Kamil E. ; Murphy, Louise B. ; Nelson, Amanda E. ; Schwartz, Todd A. ; Helmick, Charles G. ; Allen, Kelli D. ; Renner, Jordan B. ; Baker, Nancy A ; Jordan, Joanne M. Less -
Description:
Objective

Symptomatic hand osteoarthritis (SHOA) is a common condition that affects hand strength and function, and causes disability in activities of daily living. Prior studies have estimated lifetime risk for symptomatic knee and hip osteoarthritis to be 45% and 25% respectively. The objective of this study is to estimate overall lifetime risk for SHOA and stratified lifetime risk by potential risk factors.

Methods

We analyzed data for 2,218 adults ≥ 45 years in the Johnston County Osteoarthritis Project, a population-based prospective cohort study in residents of Johnston County, North Carolina. Data were collected in two cycles (1999–2004 and 2005–2010). SHOA was defined as having both self-reported symptoms and radiographic OA in the same hand. Lifetime risk, defined as the proportion of the population who will develop SHOA in at least one hand by age 85, was estimated from models using generalized estimating equations methodology.

Results

Overall, the lifetime risk of SHOA is 39.8% (95% confidence interval (CI): 34.4, 45.3). Nearly one in two women (47.2%; 95% CI: 40.6, 53.9) will develop SHOA by age 85 compared with one in four men (24.6%; 95% CI: 19.5, 30.5). Race-specific estimates are 41.4% (95% CI: 35.5, 47.6) among whites and 29.2% (95% CI: 20.5, 39.7) among blacks. Lifetime risk among individuals with obesity (47.1%, 95% CI: 37.8, 56.7) is 11 percentage point higher than those without obesity (36.1%, 95% CI: 29.7, 42.9).

Conclusion

These findings demonstrate the substantial burden of SHOA overall and in subgroups. Increased use of public health and clinical interventions is needed to address its impact.


Subject:
[+]
African Americans
Aged
Aged, 80 And Over
Confidence Intervals
Female
Hand
Humans
Male
Middle Aged
Models, Statistical
Obesity
Osteoarthritis
Radiography
Risk Factors
Sex Factors
Whites

Source:
Arthritis Rheumatol. 69(6):1204-1212.
Pubmed ID:
28470947
Pubmed Central ID:
PMC5449255
Document Type:
Journal Article
Funding:
P60 AR049465/AR/NIAMS NIH HHS/United States ; U01 DP006266/DP/NCCDPHP CDC HHS/United States ; P60 AR030701/AR/NIAMS NIH HHS/United States ; P60 AR064166/AR/NIAMS NIH HHS/United States ; CC999999/Intramural CDC HHS/United States ; ... More +
P60 AR049465/AR/NIAMS NIH HHS/United States ; U01 DP006266/DP/NCCDPHP CDC HHS/United States ; P60 AR030701/AR/NIAMS NIH HHS/United States ; P60 AR064166/AR/NIAMS NIH HHS/United States ; CC999999/Intramural CDC HHS/United States ; U01 DP003206/DP/NCCDPHP CDC HHS/United States Less -
Place as Subject:
North Carolina
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:4c5bb400df6cbfdb90aa16ed5e6a22cd99b912a051fc846d6e94c982e1523418
File Type:

Supporting Files

• 	NIHMS859089-supplement-Supp_AppendixS1.docx	docx
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