Lifetime Risk of Symptomatic Hand Osteoarthritis: The Johnston County Osteoarthritis Project

Details

• Alternative Title:
  Arthritis Rheumatol
• Personal Author:
  Qin, Jin ; Barbour, Kamil E. ; Murphy, Louise B. ; Nelson, Amanda E. ; Schwartz, Todd A. ; Helmick, Charles G. ; Allen, Kelli D. ; Renner, Jordan B. ; Baker, Nancy A ; Jordan, Joanne M.
• Description:
  Objective
  
  Symptomatic hand osteoarthritis (SHOA) is a common condition that affects hand strength and function, and causes disability in activities of daily living. Prior studies have estimated lifetime risk for symptomatic knee and hip osteoarthritis to be 45% and 25% respectively. The objective of this study is to estimate overall lifetime risk for SHOA and stratified lifetime risk by potential risk factors.
  
  Methods
  
  We analyzed data for 2,218 adults ≥ 45 years in the Johnston County Osteoarthritis Project, a population-based prospective cohort study in residents of Johnston County, North Carolina. Data were collected in two cycles (1999–2004 and 2005–2010). SHOA was defined as having both self-reported symptoms and radiographic OA in the same hand. Lifetime risk, defined as the proportion of the population who will develop SHOA in at least one hand by age 85, was estimated from models using generalized estimating equations methodology.
  
  Results
  
  Overall, the lifetime risk of SHOA is 39.8% (95% confidence interval (CI): 34.4, 45.3). Nearly one in two women (47.2%; 95% CI: 40.6, 53.9) will develop SHOA by age 85 compared with one in four men (24.6%; 95% CI: 19.5, 30.5). Race-specific estimates are 41.4% (95% CI: 35.5, 47.6) among whites and 29.2% (95% CI: 20.5, 39.7) among blacks. Lifetime risk among individuals with obesity (47.1%, 95% CI: 37.8, 56.7) is 11 percentage point higher than those without obesity (36.1%, 95% CI: 29.7, 42.9).
  
  Conclusion
  
  These findings demonstrate the substantial burden of SHOA overall and in subgroups. Increased use of public health and clinical interventions is needed to address its impact.
  
  
• Subjects:
  Aged Aged, 80 And Over Black Or African American Confidence Intervals Female Hand Humans Male Middle Aged Models, Statistical Obesity Osteoarthritis Radiography Risk Factors Sex Factors White People

  More +
• Source:
  Arthritis Rheumatol. 69(6):1204-1212.
• Pubmed ID:
  28470947
• Pubmed Central ID:
  PMC5449255
• Document Type:
  Journal Article
• Funding:
  P60 AR049465/AR/NIAMS NIH HHS/United States ; U01 DP006266/DP/NCCDPHP CDC HHS/United States ; P60 AR030701/AR/NIAMS NIH HHS/United States ; P60 AR064166/AR/NIAMS NIH HHS/United States ; CC999999/Intramural CDC HHS/United States ; U01 DP003206/DP/NCCDPHP CDC HHS/United States
• Place as Subject:
  North Carolina
• Volume:
  69
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:4c5bb400df6cbfdb90aa16ed5e6a22cd99b912a051fc846d6e94c982e1523418
• Download URL:
  https://stacks.cdc.gov/view/cdc/45940/cdc_45940_DS1.pdf
• File Type:
  [PDF - 791.41 KB ]