Details:

Alternative Title:
Pediatrics
Personal Author:
Lanzieri, Tatiana M. ; Chung, Winnie ; Flores, Marily ; Blum, Peggy ; Caviness, A. Chantal ; ... More +
Lanzieri, Tatiana M. ; Chung, Winnie ; Flores, Marily ; Blum, Peggy ; Caviness, A. Chantal ; Bialek, Stephanie R. ; Grosse, Scott D. ; Miller, Jerry A. ; Demmler-Harrison, Gail Less -
Description:
Objectives

To assess the prevalence, characteristics, and risk of sensorineural hearing loss (SNHL) through 18 years of age in children with congenital CMV infection identified through hospital-based newborn screening who were asymptomatic at birth compared to uninfected children.

Methods

We included 92 case-patients and 51 controls assessed using auditory brainstem response and behavioral audiometry. We used Kaplan-Meier survival analysis to estimate prevalence of SNHL, defined as ≥25 dB hearing level (HL) at any frequency, and Cox proportional hazards regression analyses to compare SNHL risk between groups.

Results

At the end of follow-up, SNHL prevalence was 25% (95% CI: 17–36%) among case-patients and 8% (95% CI: 3–22%) in controls (hazard ratio (HR): 4.0; 95% CI: 1.2–14.5; p-value=0.02). Among children without SNHL by age 5 years, the risk of delayed-onset SNHL was not significantly greater for case-patients than for controls (HR: 1.6; 95% CI: 0.4–6.1; P=0.5). Among case-patients, the risk of delayed-onset SNHL was significantly greater among those with unilateral congenital/early-onset loss than those without (hazard ratio: 6.9; 95% CI: 2.5–19.1; P<0.01). At the end of follow-up, the prevalence of severe to profound bilateral SNHL among case-patients was 2% (95% CI: 1–9%).

Conclusions

Delayed-onset and progression of SNHL among children with asymptomatic congenital CMV infection continued to occur throughout adolescence. However, the risk of developing SNHL after age 5 years among case-patients was not different than in uninfected children. An estimated 2% of case-patients developed SNHL severe enough to be candidates for cochlear implantation.


Subjects:
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Adolescent Age Of Onset Article Asymptomatic Infections Case-Control Studies Child Child, Preschool Cytomegalovirus Infections Deafness Disease Progression Evoked Potentials, Auditory, Brain Stem Female Hearing Loss, Sensorineural Humans Infant Infant, Newborn Male Neonatal Screening Prevalence Proportional Hazards Models Severity Of Illness Index
Source:
Pediatrics. 139(3)
Pubmed ID:
28209771
Pubmed Central ID:
PMC5330400
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States ; M01 RR000188/RR/NCRR NIH HHS/United States ; P30 HD024064/HD/NICHD NIH HHS/United States
CC999999/Intramural CDC HHS/United States ; M01 RR000188/RR/NCRR NIH HHS/United States ; P30 HD024064/HD/NICHD NIH HHS/United States Less -
Place as Subject:
Texas
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:c3f7b154ecbeda66a500b33068a05c3ff34a0e5ff77014aed0065a28adce1284
Download URL:
https://stacks.cdc.gov/view/cdc/45933/cdc_45933_DS1.pdf
File Type:

Supporting Files

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