Should You Follow the Better-Hearing Ear for Congenital Cytomegalovirus Infection and Isolated Sensorineural Hearing Loss?

Torrecillas, Vanessa; Allen, Chelsea M.; Greene, Tom; Park, Albert; Chung, Winnie; Lanzieri, Tatiana M.; Demmler-Harrison, Gail

doi:10.1177/0194599819880348

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Should You Follow the Better-Hearing Ear for Congenital Cytomegalovirus Infection and Isolated Sensorineural Hearing Loss?

1 2020
By Torrecillas, Vanessa ; Allen, Chelsea M. ; Greene, Tom ; ...
http://dx.doi.org/10.1177/0194599819880348
Source: Otolaryngol Head Neck Surg. 162(1):114-120

[PDF-279.91 KB]

English

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Details:

Alternative Title:

Otolaryngol Head Neck Surg
Personal Author:

Torrecillas, Vanessa ; Allen, Chelsea M. ; Greene, Tom ; Park, Albert ; Chung, Winnie ; ... More +

Torrecillas, Vanessa ; Allen, Chelsea M. ; Greene, Tom ; Park, Albert ; Chung, Winnie ; Lanzieri, Tatiana M. ; Demmler-Harrison, Gail Less -
Description:

Objective.

To describe the progression of sensorineural hearing loss (SNHL) in the better- and poorer-hearing ears in children with asymptomatic congenital cytomegalovirus (CMV) infection with isolated SNHL.

Study Design.

Longitudinal prospective cohort study.

Setting.

Tertiary medical center.

Subjects and Methods.

We analyzed hearing thresholds of the better- and poorer-hearing ears of 16 CMV-infected patients with isolated congenital/early-onset or delayed-onset SNHL identified through hospital-based CMV screening of >30,000 newborns from 1982 to 1992.

Results.

By 12 months of age, 4 of 7 patients with congenital/early-onset SNHL developed worsening thresholds in the poorer-hearing ear, and 1 had an improvement in the better-hearing ear. By 18 years of age, all 7 patients had worsening thresholds in the poorer-hearing ear and 3 patients had worsening thresholds in the better-hearing ear. Hearing loss first worsened at a mean age of 2 and 6 years in the poorer-and better-hearing ears, respectively. Nine patients were diagnosed with delayed-onset SNHL (mean age of 9 years vs 12 years for the poorer- and better-hearing ears), 6 of whom had worsening thresholds in the poorer-hearing ear and 1 in both ears.

Conclusion.

In most children with congenital CMV infection and isolated SNHL, the poorer-hearing ear worsened earlier and more precipitously than the better-hearing ear. This study suggests that monitoring individual hearing thresholds in both ears is important for appropriate interventions and future evaluation of efficacy of antiviral treatment.
Subjects:

[+]

Age Factors Age Of Onset Asymptomatic Diseases Auditory Threshold Child Child, Preschool Cohort Studies Cytomegalovirus Infections Disease Progression Female Follow-Up Studies Hearing Loss, Sensorineural Hearing Tests Humans Infant Infant, Newborn Longitudinal Studies Male Monitoring, Physiologic Neonatal Screening Prospective Studies Risk Assessment Severity Of Illness Index Time Factors United States
Keywords:

[+]

Asymptomatic Buprenorphine Cytomegalovirus Hearing Infection Methadone Mortality Naltrexone Sensorineural Hearing Loss Treatment
Source:

Otolaryngol Head Neck Surg. 162(1):114-120
Pubmed ID:

31593522
Pubmed Central ID:

PMC7274837
Document Type:

Journal Article
Funding:

UL1 RR025764/RR/NCRR NIH HHSUnited States/ ; M01 RR000188/RR/NCRR NIH HHSUnited States/ ; P30 HD024064/HD/NICHD NIH HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; UL1 TR000105/TR/NCATS NIH HHSUnited States/ ; ... More +

UL1 RR025764/RR/NCRR NIH HHSUnited States/ ; M01 RR000188/RR/NCRR NIH HHSUnited States/ ; P30 HD024064/HD/NICHD NIH HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; UL1 TR000105/TR/NCATS NIH HHSUnited States/ ; U01 DC014706/DC/NIDCD NIH HHSUnited States/ Less -
Volume:

162
Issue:

1
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha-512:6150689dcee86e68efc069169b30128999863ae426841c887ce7fcf22a83e2861641aa7b619c5b7cb3a519726f4bd4554304d4cfb519ccd3601d80dff70fc438
Download URL:

https://stacks.cdc.gov/view/cdc/88957/cdc_88957_DS1.pdf
File Type:

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