Single-Dose Replication-Defective VSV-based Nipah Virus Vaccines Provide Protection from Lethal Challenge in Syrian Hamsters

Lo, Michael K.; Bird, Brian H.; Chattopadhyay, Anasuya; Drew, Clifton P.; Martin, Brock E.; Coleman, Joann D.; Rose, John K.; Nichol, Stuart T.; Spiropoulou, Christina F.

doi:10.1016/j.antiviral.2013.10.012

i

Single-Dose Replication-Defective VSV-based Nipah Virus Vaccines Provide Protection from Lethal Challenge in Syrian Hamsters

Supporting Files

October 30 2013
By Lo, Michael K. ; Bird, Brian H. ; Chattopadhyay, Anasuya ; ...

File Language:

English

Details

Alternative Title:

Antiviral Res
Personal Author:

Lo, Michael K. ; Bird, Brian H. ; Chattopadhyay, Anasuya ; Drew, Clifton P. ; Martin, Brock E. ; Coleman, Joann D. ; Rose, John K. ; Nichol, Stuart T. ; Spiropoulou, Christina F.
Description:

Nipah virus (NiV) continues to cause outbreaks of fatal human encephalitis due to spillover from its bat reservoir. We determined that a single dose of replication-defective vesicular stomatitis virus (VSV)-based vaccine vectors expressing either the NiV fusion (F) or attachment (G) glycoproteins protected hamsters from over 1000 times LD50 NiV challenge. This highly effective single-dose protection coupled with an enhanced safety profile makes these candidates ideal for potential use in livestock and humans.
Subjects:

Animals Article Cricetinae Disease Models, Animal Drug Carriers Glycoproteins Hamster Henipavirus Henipavirus Infections Mesocricetus Nipah Nipah Virus Single-dose Survival Analysis Vaccine Vaccines, Synthetic Vesiculovirus Viral Structural Proteins Viral Vaccines VSV
Source:

Antiviral Res. 101
Pubmed ID:

24184127
Pubmed Central ID:

PMC3874889
Document Type:

Journal Article
Funding:

CC999999/Intramural CDC HHS/United States ; T32 AI007610/AI/NIAID NIH HHS/United States ; U54 AI057158/AI/NIAID NIH HHS/United States ; U54-AI057158/AI/NIAID NIH HHS/United States
Volume:

101
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:1157304ad7286e9923fed82b5d187628b5848e60465173df73b4459dfb418a58
Download URL:

https://stacks.cdc.gov/view/cdc/45895/cdc_45895_DS1.pdf
File Type:

[PDF - 995.25 KB ]

File Language:

English

ON THIS PAGE

Details Supporting Files

CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.