Details:

Alternative Title:
Antiviral Res
Personal Author:
Lo, Michael K. ; Bird, Brian H. ; Chattopadhyay, Anasuya ; Drew, Clifton P. ; Martin, Brock E. ; ... More +
Lo, Michael K. ; Bird, Brian H. ; Chattopadhyay, Anasuya ; Drew, Clifton P. ; Martin, Brock E. ; Coleman, Joann D. ; Rose, John K. ; Nichol, Stuart T. ; Spiropoulou, Christina F. Less -
Description:
Nipah virus (NiV) continues to cause outbreaks of fatal human encephalitis due to spillover from its bat reservoir. We determined that a single dose of replication-defective vesicular stomatitis virus (VSV)-based vaccine vectors expressing either the NiV fusion (F) or attachment (G) glycoproteins protected hamsters from over 1000 times LD50 NiV challenge. This highly effective single-dose protection coupled with an enhanced safety profile makes these candidates ideal for potential use in livestock and humans.
Subject:
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Animals Article Cricetinae Disease Models, Animal Drug Carriers Glycoproteins Hamster Henipavirus Henipavirus Infections Mesocricetus Nipah Nipah Virus Single-dose Survival Analysis Vaccine Vaccines, Synthetic Vesiculovirus Viral Structural Proteins Viral Vaccines VSV
Source:
Antiviral Res. 101
Pubmed ID:
24184127
Pubmed Central ID:
PMC3874889
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States ; T32 AI007610/AI/NIAID NIH HHS/United States ; U54 AI057158/AI/NIAID NIH HHS/United States ; U54-AI057158/AI/NIAID NIH HHS/United States
CC999999/Intramural CDC HHS/United States ; T32 AI007610/AI/NIAID NIH HHS/United States ; U54 AI057158/AI/NIAID NIH HHS/United States ; U54-AI057158/AI/NIAID NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:1157304ad7286e9923fed82b5d187628b5848e60465173df73b4459dfb418a58
Download URL:
https://stacks.cdc.gov/view/cdc/45895/cdc_45895_DS1.pdf
File Type:

Supporting Files

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