Azithromycin Resistance and Decreased Ceftriaxone Susceptibility in Neisseria gonorrhoeae, Hawaii, USA

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Papp, John R. ; Abrams, A. Jeanine ; Nash, Evelyn ; Katz, Alan R. ; Kirkcaldy, Robert D. ; O’Connor, Norman P. ; O’Brien, Pamela S. ; Harauchi, Derek H. ; Maningas, Eloisa V. ; Soge, Olusegun O. ; Kersh, Ellen N. ; Komeya, Alan ; Tomas, Juval E. ; Wasserman, Glenn M. ; Kunimoto, Gail Y. ; Trees, David L. ; Whelen, A. Christian
• Description:
  During 2016, eight Neisseria gonorrhoeae isolates from 7 patients in Hawaii were resistant to azithromycin; 5 had decreased in vitro susceptibility to ceftriaxone. Genomic analysis demonstrated a distinct phylogenetic clade when compared with local contemporary strains. Continued evolution and widespread transmission of these strains might challenge the effectiveness of current therapeutic options.
• Subjects:
  Anti-Bacterial Agents Azithromycin Dispatch Drug Resistance, Bacterial Genome, Bacterial Gonorrhea Humans Microbial Sensitivity Tests Multilocus Sequence Typing Neisseria Gonorrhoeae Phylogeny Sexually Transmitted Diseases, Bacterial

  More +
• Source:
  Emerg Infect Dis. 23(5):830-832.
• Pubmed ID:
  28418303
• Pubmed Central ID:
  PMC5403062
• Document Type:
  Journal Article
• Place as Subject:
  Hawaii
• Location:
  Oceania
• Volume:
  23
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:952868a6af331488f6484b657aa9ce715ec3b8cc848f94a7e20ccdd224c959d1
• Download URL:
  https://stacks.cdc.gov/view/cdc/45647/cdc_45647_DS1.pdf
• File Type:
  [PDF - 507.27 KB ]