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Population Genomics of Legionella longbeachae and Hidden Complexities of Infection Source Attribution
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May 2017
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Source: Emerg Infect Dis. 23(5):750-757.
[PDF-3.54 MB]
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Alternative Title:Emerg Infect Dis
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Description:Legionella longbeachae is the primary cause of legionellosis in Australasia and Southeast Asia and an emerging pathogen in Europe and the United States; however, our understanding of the population diversity of L. longbeachae from patient and environmental sources is limited. We analyzed the genomes of 64 L. longbeachae isolates, of which 29 were from a cluster of legionellosis cases linked to commercial growing media in Scotland in 2013 and 35 were non-outbreak-associated isolates from Scotland and other countries. We identified extensive genetic diversity across the L. longbeachae species, associated with intraspecies and interspecies gene flow, and a wide geographic distribution of closely related genotypes. Of note, we observed a highly diverse pool of L. longbeachae genotypes within compost samples that precluded the genetic establishment of an infection source. These data represent a view of the genomic diversity of L. longbeachae that will inform strategies for investigating future outbreaks.
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Pubmed ID:28418314
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Pubmed Central ID:PMC5403047
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Document Type:
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Volume:23
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Issue:5
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