Racial/Ethnic Differences in the Impact of Neighborhood Social and Built Environment on Breast Cancer Risk: The Neighborhoods and Breast Cancer Study

Details

• Alternative Title:
  Cancer Epidemiol Biomarkers Prev
• Personal Author:
  Conroy, Shannon M. ; Shariff-Marco, Salma ; Koo, Jocelyn ; Yang, Juan ; Keegan, Theresa H.M. ; Sangaramoorthy, Meera ; Hertz, Andrew ; Nelson, David O. ; Cockburn, Myles ; Satariano, William A. ; Yen, Irene H. ; Ponce, Ninez A. ; John, Esther M. ; Gomez, Scarlett L.
• Description:
  Background
  
  Neighborhood socioeconomic status (nSES) has been found to be associated with breast cancer risk. It remains unclear whether this association applies across racial/ethnic groups independent of individual-level factors, and is attributable to other neighborhood characteristics.
  
  Methods
  
  We examined the independent and joint associations of education and nSES with odds of breast cancer. Residential addresses were geocoded for 2,838 cases and 3,117 controls and linked to nSES and social and built environment characteristics. We estimated odds ratios (OR) and 95% confidence intervals (CI) using multilevel logistic regression controlling for individual-level breast cancer risk factors, and assessed the extent to which nSES associations were due to neighborhood characteristics.
  
  Results
  
  Women living in the highest versus lowest nSES quintile had a nearly two-fold greater odds of breast cancer, with elevated odds (adjusted ORs, 95% CI) for non-Hispanic whites (NHWs) (2.27, 1.45–3.56), African Americans (1.74, 1.07–2.83), U.S.-born Hispanics (1.82, 1.19–2.79), and foreign-born Hispanics (1.83, 1.06–3.17). Considering education and nSES jointly, ORs were increased for: low education/high nSES NHWs (1.83, 1.14–2.95), high education/high nSES NHWs (1.64, 1.06–2.54), and high education/high nSES foreign-born Hispanics (2.17, 1.52–3.09) relative to their race/ethnicity/nativity-specific low education/low nSES counterparts. Adjustment for urban and mixed-land use characteristics attenuated the nSES associations for most racial/ethnic/nativity groups except NHWs.
  
  Conclusions
  
  Our study provides empirical evidence for a role of neighborhood environments in breast cancer risk, specifically social and built environment attributes.
  
  Impact
  
  Considering the role of neighborhood characteristics among diverse populations may offer insights to understand racial/ethnic disparities in breast cancer risk.
  
  
• Subjects:
  Adolescent Adult Aged Breast Neoplasms Case-Control Studies Cohort Studies Female Humans Logistic Models Middle Aged Racial Groups Registries Residence Characteristics Risk Factors Social Class Surveys And Questionnaires Young Adult

  More +
• Source:
  Cancer Epidemiol Biomarkers Prev. 26(4):541-552.
• Pubmed ID:
  28196846
• Pubmed Central ID:
  PMC5380527
• Document Type:
  Journal Article
• Funding:
  HHSN261201000035C/PC,CA/International ; HHSN261201000140C/CA/NCI NIH HHS/United States ; UM1 CA164920/CA/NCI NIH HHS/United States ; R01 CA140058/CA/NCI NIH HHS/United States ; HHSN261201000035I/CA/NCI NIH HHS/United States ; R01 CA063446/CA/NCI NIH HHS/United States ; HHSN261201000034C/CA/NCI NIH HHS/United States ; U58 DP003862/DP/NCCDPHP CDC HHS/United States
• Place as Subject:
  California
• Volume:
  26
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:326c07214324634dd9efba71e7d94d4a37ca6187e27de3885211b02764247c98
• Download URL:
  https://stacks.cdc.gov/view/cdc/45004/cdc_45004_DS1.pdf
• File Type:
  [PDF - 544.33 KB ]