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Research to Practice Implications of High-Risk Genotypes for Beryllium Sensitization and Disease

  • Published Date:

    Sep 2016

  • Source:
    J Occup Environ Med. 58(9):855-860.
Filetype[PDF-193.66 KB]

  • Alternative Title:
    J Occup Environ Med
  • Description:
    Objective Beryllium workers may better understand their genetic susceptibility to chronic beryllium disease (CBD) expressed as population-based prevalence, rather than odds ratios from case-control studies. Methods We calculated CBD prevalences from allele-specific DNA sequences of 853 workers for Human Leukocyte Antigen (HLA)-DPB1 genotypes and groups characterized by number of E69-containing alleles and by calculated surface electronegativity of HLA-DPB1. Results Of 18 groups of at least 10 workers with specific genotypes, CBD prevalence was highest, 72.7%, for the HLA-DPB1*02:01:02/DPB1*17:01 genotype. Population-based grouped genotypes with two E69 alleles wherein one allele had −9 surface charge had a beryllium sensitization (BeS) of 52.6% and a CBD prevalence of 42.1%. Conclusions The high CBD and BeS prevalences associated with −9-charged E69 alleles and two E69s suggest that workers may benefit from knowing their genetic susceptibility in deciding whether to avoid future beryllium exposure.
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