Swine Influenza Virus (H1N2) Characterization and Transmission in Ferrets, Chile

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Bravo-Vasquez, Nicolás ; Karlsson, Erik A. ; Jimenez-Bluhm, Pedro ; Meliopoulos, Victoria ; Kaplan, Bryan ; Marvin, Shauna ; Cortez, Valerie ; Freiden, Pamela ; Beck, Melinda A. ; Hamilton-West, Christopher ; Schultz-Cherry, Stacey
• Description:
  Phylogenetic analysis of the influenza hemagglutinin gene (HA) has suggested that commercial pigs in Chile harbor unique human seasonal H1-like influenza viruses, but further information, including characterization of these viruses, was unavailable. We isolated influenza virus (H1N2) from a swine in a backyard production farm in Central Chile and demonstrated that the HA gene was identical to that in a previous report. Its HA and neuraminidase genes were most similar to human H1 and N2 viruses from the early 1990s and internal segments were similar to influenza A(H1N1)pdm09 virus. The virus replicated efficiently in vitro and in vivo and transmitted in ferrets by respiratory droplet. Antigenically, it was distinct from other swine viruses. Hemagglutination inhibition analysis suggested that antibody titers to the swine Chilean H1N2 virus were decreased in persons born after 1990. Further studies are needed to characterize the potential risk to humans, as well as the ecology of influenza in swine in South America.
• Subjects:
  Animal Diseases Animals Antibodies, Viral Cell Line Female Ferrets Geography, Medical Hemagglutination Inhibition Tests High-Throughput Nucleotide Sequencing Humans Influenza, Human Influenza A Virus, H1N2 Subtype Orthomyxoviridae Infections Public Health Surveillance Rna, Viral Seasons Seroepidemiologic Studies Swine Swine Diseases Virus Replication

  More +
• Source:
  Emerg Infect Dis. 23(2):241-251.
• Pubmed ID:
  28098524
• Pubmed Central ID:
  PMC5324791
• Document Type:
  Journal Article
• Place as Subject:
  Chile
• Volume:
  23
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:1fa71bfbc82381ac035275719d40759908cd58f47eb121394416b388dbd6a254
• Download URL:
  https://stacks.cdc.gov/view/cdc/44387/cdc_44387_DS1.pdf
• File Type:
  [PDF - 4.89 MB ]