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Infection With Hepatitis C Virus Genotype 3 is an Independent Risk Factor for End-stage Liver Disease, Hepatocellular Carcinoma, and Liver-related Death
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Oct 17 2016
Source: Clin Gastroenterol Hepatol 15(3):431-437e2
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Alternative Title:Clin Gastroenterol Hepatol
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Description:Background & Aims
Few studies have examined factors associated with disease progression in hepatitis C virus (HCV) infection We examined the association of 11 risk factors with adverse outcomes in a population-based prospective cohort observational study of Alaska Native/American Indian persons with chronic HCV infection
Methods
We collected data from a population-based cohort study of liver-related adverse outcomes of infection in American Indian/Alaska Native persons with chronic HCV living in Alaska, recruited from 1995 through 2012 We calculated adjusted hazard ratios (aHR) and 95% CIs for end-stage liver disease (ESLD; presence of ascites, esophageal varices, hepatic encephalopathy, or coagulopathy), hepatocellular carcinoma (HCC), and liver-related death using a Cox proportional hazards model
Results
We enrolled 1080 participants followed for 11,171 person-years (mean, 103 years); 66%, 19%, and 14% were infected with HCV genotypes 1, 2, and 3, respectively On multivariate analysis, persons infected with HCV genotype 3 had a significantly increased risk of developing all 3 adverse outcomes Their aHR for ESLD was 21 (95% CI, 15–30), aHR for HCC was 31 (95% CI, 14–66), and aHR for liver-related death was 24 (95% CI, 15–40) compared to genotype 1 Heavy alcohol use was an age-adjusted risk factor for ESLD (aHR, 22; 95% CI, 16–32), and liver-related death (aHR: 29; 95% CI, 18–46) Obesity was a risk factor for ESLD (aHR, 14; 95% CI, 10–19, and diabetes was a risk factor for ESLD (aHR, 15; 95% CI, 11–22) Male sex was a risk factor for HCC (aHR, 36; 95% CI, 16–82)
Conclusions
In a population-based cohort study of American Indian/Alaska Native persons with chronic HCV infection, we found those infected with HCV genotype 3 to be at high risk for ESLD, HCC, and liver-related death
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Pubmed ID:27765729
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Pubmed Central ID:PMC5316337
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