Hospital-based Surveillance for Rotavirus Gastroenteritis Among Young Children in Bangladesh

Details

• Alternative Title:
  Pediatr Infect Dis J
• Personal Author:
  Satter, Syed M. ; Gastanaduy, Paul A. ; Islam, Khaleda ; Rahman, Mahmudur ; Rahman, Mustafizur ; Luby, Stephen P. ; Heffelfinger, James D. ; Parashar, Umesh D. ; Gurley, Emily S.
• Description:
  Background:
  
  In anticipation of introduction of a rotavirus vaccine into the national immunization program of Bangladesh, active hospital-based surveillance was initiated to provide prevaccine baseline data on rotavirus disease.
  
  Methods:
  
  Children 5 years of age and younger admitted with acute gastroenteritis (AGE) (≥3 watery or looser-than-normal stools or ≥1 episode of forceful vomiting) at 7 hospitals throughout Bangladesh were identified. Clinical information and stool specimens were collected from every 4th patient. Specimens were tested for rotavirus antigen by enzyme immunoassays; 25% of detected rotaviruses were genotyped.
  
  Results:
  
  From July 2012 to June 2015, rotavirus was detected in 2432 (64%) of 3783 children hospitalized for AGE. Eight enrolled children died, including 4 (50%) who were rotavirus positive. Rotavirus was detected year-round in Bangladesh with peak detection rates of >80% during November–February. Most (86%) rotavirus AGE cases were 6–23 months of age. Sixty-nine percent of children with rotavirus had severe disease (Vesikari score, ≥11). Among 543 strains genotyped, G1P[8] (31%) and G12P[8] (29%) were the most common.
  
  Conclusions:
  
  Rotavirus is a major cause of morbidity in Bangladeshi children, accounting for nearly two-thirds of AGE hospitalizations. These data highlight the potential value of rotavirus vaccination in Bangladesh, and will be the key for future measurement of vaccine impact.
  
  
• Subjects:
  Child, Preschool Cohort Studies Female Gastroenteritis/epidemiology Gastroenteritis/prevention & Control Gastroenteritis/virology Hospitalization Humans Infant Infant, Newborn Male Original Studies Public Health Surveillance Rotavirus Rotavirus Infections/epidemiology Rotavirus Infections/prevention & Control Rotavirus Infections/virology Rotavirus Vaccines Vaccination

  More +
• Source:
  Pediatr Infect Dis J. 2016; 36(2):168-172.
• Pubmed ID:
  27798545
• Pubmed Central ID:
  PMC5242217
• Document Type:
  Journal Article
• Place as Subject:
  Bangladesh
• Volume:
  36
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:14b2930c6a41a3a9831608dbac8e572e9020c2deb4fcc124e831ca67f7f65352
• Download URL:
  https://stacks.cdc.gov/view/cdc/44234/cdc_44234_DS1.pdf
• File Type:
  [PDF - 461.50 KB ]