Details:

Alternative Title:
Pediatr Infect Dis J
Publisher's site:
http://dx.doi.org/10.1097/INF.0000000000001381
Personal Author:
Satter, Syed M. ; Gastanaduy, Paul A. ; Islam, Khaleda ; Rahman, Mahmudur ; Rahman, Mustafizur ; ... More +
Satter, Syed M. ; Gastanaduy, Paul A. ; Islam, Khaleda ; Rahman, Mahmudur ; Rahman, Mustafizur ; Luby, Stephen P. ; Heffelfinger, James D. ; Parashar, Umesh D. ; Gurley, Emily S. Less -
Description:
Background:

In anticipation of introduction of a rotavirus vaccine into the national immunization program of Bangladesh, active hospital-based surveillance was initiated to provide prevaccine baseline data on rotavirus disease.

Methods:

Children 5 years of age and younger admitted with acute gastroenteritis (AGE) (≥3 watery or looser-than-normal stools or ≥1 episode of forceful vomiting) at 7 hospitals throughout Bangladesh were identified. Clinical information and stool specimens were collected from every 4th patient. Specimens were tested for rotavirus antigen by enzyme immunoassays; 25% of detected rotaviruses were genotyped.

Results:

From July 2012 to June 2015, rotavirus was detected in 2432 (64%) of 3783 children hospitalized for AGE. Eight enrolled children died, including 4 (50%) who were rotavirus positive. Rotavirus was detected year-round in Bangladesh with peak detection rates of >80% during November–February. Most (86%) rotavirus AGE cases were 6–23 months of age. Sixty-nine percent of children with rotavirus had severe disease (Vesikari score, ≥11). Among 543 strains genotyped, G1P[8] (31%) and G12P[8] (29%) were the most common.

Conclusions:

Rotavirus is a major cause of morbidity in Bangladeshi children, accounting for nearly two-thirds of AGE hospitalizations. These data highlight the potential value of rotavirus vaccination in Bangladesh, and will be the key for future measurement of vaccine impact.


Subject:
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Child, Preschool Cohort Studies Female Gastroenteritis/epidemiology Gastroenteritis/prevention & Control Gastroenteritis/virology Hospitalization Humans Infant Infant, Newborn Male Original Studies Public Health Surveillance Rotavirus Rotavirus Infections/epidemiology Rotavirus Infections/prevention & Control Rotavirus Infections/virology Rotavirus Vaccines Vaccination
Source:
Pediatr Infect Dis J. 2016; 36(2):168-172.
Pubmed ID:
27798545
Pubmed Central ID:
PMC5242217
Document Type:
Journal Article
Place as Subject:
Bangladesh
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:14b2930c6a41a3a9831608dbac8e572e9020c2deb4fcc124e831ca67f7f65352
Download URL:
https://stacks.cdc.gov/view/cdc/44234/cdc_44234_DS1.pdf
File Type:

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