Liquefied petroleum gas or biomass cooking and severe infant pneumonia

McCollum, Eric D.; McCracken, John P.; Kirby, Miles A.; Grajeda, Laura M.; Hossen, Shakir; Moulton, Lawrence H.; Simkovich, Suzanne; Goodman-Palmer, Dina; Rosa, Ghislaine; Mukeshimana, Alexie; Balakrishnan, Kalpana; Thangavel, Gurusamy; Garg, Sarada S.; Castañaza, Adly; Thompson, Lisa M.; Diaz-Artiga, Anaité; Papageorghiou, Aris T.; Davila-Roman, Victor G.; Underhill, Lindsay; Hartinger, Stella; Williams, Kendra N.; Nicolaou, Laura; Chang, Howard H.; Lovvorn, Amy E.; Rosenthal, Joshua; Pillarisetti, Ajay; Ye, Wenlu; Naeher, Luke P.; Johnson, Michael A.; Waller, Lance A.; Jabbarzadeh, Shirin; Wang, Jiantong; Chen, Yunyun; Steenland, Kyle; Clasen, Thomas F.; Peel, Jennifer L.; Checkley, William

doi:10.1056/NEJMoa2305681

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Liquefied petroleum gas or biomass cooking and severe infant pneumonia

1 04 2024
By McCollum, Eric D. ; McCracken, John P. ; Kirby, Miles A. ; ...
http://dx.doi.org/10.1056/NEJMoa2305681
Source: N Engl J Med. 390(1):32-43

[PDF-654.34 KB]

English

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Details:

Alternative Title:

N Engl J Med
Personal Author:

McCollum, Eric D. ; McCracken, John P. ; Kirby, Miles A. ; Grajeda, Laura M. ; Hossen, Shakir ; ... More +

McCollum, Eric D. ; McCracken, John P. ; Kirby, Miles A. ; Grajeda, Laura M. ; Hossen, Shakir ; Moulton, Lawrence H. ; Simkovich, Suzanne ; Goodman-Palmer, Dina ; Rosa, Ghislaine ; Mukeshimana, Alexie ; Balakrishnan, Kalpana ; Thangavel, Gurusamy ; Garg, Sarada S. ; Castañaza, Adly ; Thompson, Lisa M. ; Diaz-Artiga, Anaité ; Papageorghiou, Aris T. ; Davila-Roman, Victor G. ; Underhill, Lindsay ; Hartinger, Stella ; Williams, Kendra N. ; Nicolaou, Laura ; Chang, Howard H. ; Lovvorn, Amy E. ; Rosenthal, Joshua ; Pillarisetti, Ajay ; Ye, Wenlu ; Naeher, Luke P. ; Johnson, Michael A. ; Waller, Lance A. ; Jabbarzadeh, Shirin ; Wang, Jiantong ; Chen, Yunyun ; Steenland, Kyle ; Clasen, Thomas F. ; Peel, Jennifer L. ; Checkley, William Less -
Description:

Background:

Household air pollution exposure is a risk factor for severe pneumonia. The effect of replacing biomass cooking with liquefied petroleum gas (LPG) cookstoves on severe infant pneumonia is uncertain.

Methods:

We conducted a randomized controlled trial among 3,200 pregnant women aged 18-34 years and 9 to <20 weeks gestation in India, Guatemala, Peru, and Rwanda May 2018–September 2021. Pregnant women were randomized to unvented LPG stoves and fuel (intervention) or continued biomass fuel cooking (control). We monitored intervention adherence and measured 24-hour personal exposure to fine particulate matter (PM2.5) in pregnant women and their offspring. The trial had 4 primary outcomes; the primary outcome described in the present report was severe pneumonia in the first year of life, identified by facility surveillance or verbal autopsy of deaths.

Results:

We randomized 3,195 pregnant women who gave birth to 3,061 infants. High intervention uptake led to reduced PM2.5 personal exposures among children (intervention median 24.2 μg/m3 (interquartile range (IQR) 17.8, 36.4); control median 66.0 μg/m3 (IQR 35.2, 132.0). There were 175 severe pneumonia episodes identified during the first year of life, with an incidence rate of 5.67 (95% confidence interval (CI) 4.55, 7.07) and 6.06 (4.81, 7.62) cases per 100-child years in intervention and controls (incidence rate ratio 0.96 [98.75% CI, 0.64, 1.44; p=0.81]. No severe adverse events associated with the intervention were reported.

Conclusions:

There was no significant difference in severe pneumonia incidence among infants of women randomized to LPG compared to biomass-burning cookstoves.
Keywords:

[+]

Adolescent Adult Air Pollution, Indoor Biomass Cooking Female Humans Infant Inhalation Exposure Internationality Maternal Exposure Particulate Matter Petroleum Pneumonia Pregnancy Prenatal Exposure Delayed Effects Young Adult
Source:

N Engl J Med. 390(1):32-43
Pubmed ID:

38169488
Pubmed Central ID:

PMC10768798
Document Type:

Journal Article
Funding:

R01 ES033530/ES/NIEHS NIH HHSUnited States/ ; T42 OH008429/OH/NIOSH CDC HHSUnited States/ ; UM1 HL134590/HL/NHLBI NIH HHSUnited States/ ; 1UM1HL134590/NH/NIH HHSUnited States/

R01 ES033530/ES/NIEHS NIH HHSUnited States/ ; T42 OH008429/OH/NIOSH CDC HHSUnited States/ ; UM1 HL134590/HL/NHLBI NIH HHSUnited States/ ; 1UM1HL134590/NH/NIH HHSUnited States/ Less -
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:2bd7d5a80400bcf7ed97e313355a42c2b0eb1ab02e5a12a7f939c73642b66d18
Download URL:

https://stacks.cdc.gov/view/cdc/150264/cdc_150264_DS1.pdf
File Type:

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